Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F20%3A00118398" target="_blank" >RIV/00216224:14740/20:00118398 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41590-020-0791-5" target="_blank" >https://www.nature.com/articles/s41590-020-0791-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41590-020-0791-5" target="_blank" >10.1038/s41590-020-0791-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans

Popis výsledku v původním jazyce

The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells-one giving rise to a functional lineage, the other to an exhausted-like one. T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a systematic approach guided by single-cell RNA-sequencing data to map the organizational structure of the human CD8(+)memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically and transcriptionally distinct stem-like CD8(+)memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data reveal the existence of parallel differentiation programs in the human CD8(+)memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines.

Název v anglickém jazyce

Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans

Popis výsledku anglicky

The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells-one giving rise to a functional lineage, the other to an exhausted-like one. T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a systematic approach guided by single-cell RNA-sequencing data to map the organizational structure of the human CD8(+)memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically and transcriptionally distinct stem-like CD8(+)memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data reveal the existence of parallel differentiation programs in the human CD8(+)memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature immunology

ISSN

1529-2908

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

14

Strana od-do

„1552“-„+“

Kód UT WoS článku

000577043300002

EID výsledku v databázi Scopus

2-s2.0-85092340566