Bystander activation in memory and antigen- inexperienced memory-like CD8 T cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00570976" target="_blank" >RIV/68378050:_____/23:00570976 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/23:10471653

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0952791523000183?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0952791523000183?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.coi.2023.102299" target="_blank" >10.1016/j.coi.2023.102299</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bystander activation in memory and antigen- inexperienced memory-like CD8 T cells

Popis výsledku v původním jazyce

Antigen-induced memory T cells undergo counterintuitive activation in an antigen-independent manner, which is called bystander response. Although it is well documented that memory CD8+ T cells produce IFN gamma and upregulate the cytotoxic program upon the stimulation with inflammatory cytokines, there is only rare evidence that this provides an actual protection against pathogens in immunocompetent individuals. One of the reasons might be numerous antigen-inexperienced memory-like T cells that are also capable of the bystander response. Little is known about the bystander protection of memory and memory-like T cells and their redundancies with innate-like lymphocytes in humans because of the interspecies differences and the lack of controlled experiments. However, it has been proposed that IL-15/ NKG2D-driven bystander activation of memory T cells drives protection or immunopathology in particular human diseases.

Název v anglickém jazyce

Bystander activation in memory and antigen- inexperienced memory-like CD8 T cells

Popis výsledku anglicky

Antigen-induced memory T cells undergo counterintuitive activation in an antigen-independent manner, which is called bystander response. Although it is well documented that memory CD8+ T cells produce IFN gamma and upregulate the cytotoxic program upon the stimulation with inflammatory cytokines, there is only rare evidence that this provides an actual protection against pathogens in immunocompetent individuals. One of the reasons might be numerous antigen-inexperienced memory-like T cells that are also capable of the bystander response. Little is known about the bystander protection of memory and memory-like T cells and their redundancies with innate-like lymphocytes in humans because of the interspecies differences and the lack of controlled experiments. However, it has been proposed that IL-15/ NKG2D-driven bystander activation of memory T cells drives protection or immunopathology in particular human diseases.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Immunology

ISSN

0952-7915

e-ISSN

1879-0372

Svazek periodika

82

Číslo periodika v rámci svazku

JUN

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

102299

Kód UT WoS článku

000955180400001

EID výsledku v databázi Scopus

2-s2.0-85150828447