Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00124240" target="_blank" >RIV/00216224:14740/21:00124240 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsami.0c19273" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.0c19273</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsami.0c19273" target="_blank" >10.1021/acsami.0c19273</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles

Popis výsledku v původním jazyce

We illustrate the development of NaDyF4-NaGdF4 core-shell nanoparticles (NPs) for targeting prostate cancer cells using a preclinical 9.4 T magnetic resonance imaging (MRI) of live animals. The NPs composed of paramagnetic Dy3+ and Gd3+ (T-2- and T-1-contrast agents, respectively) demonstrate proton relaxivities of r(1) = 20.2 mM(-1) s(-1) and r(2) = 32.3 mM(-1) s(-1) at clinical 3 T and r(1) = 9.4 mM(-1) s(-1) and r(2) = 144.7 mM(-1) s(-1) at preclinical 9.4 T. The corresponding relaxivity values per NP are r(1) = 19.4 x 105 mM(NP)(-1) s(-1) and r(2) = 33.0 x 10(5) mMNP(-1) s(-1) at 3 T and r(1) = 9.0 x 105 mM(NP)(-1) s(-1) and r(2) = 147.0 x 10(5) mM(NP)(-1) s(-1) at 9.4 T. In vivo active targeting of human prostate tumors grown in nude mice revealed docking of anti-prostate-specific membrane antigen (PSMA) antibody-tagged NPs at tumor sites post-24 h of their intravenous injection. On the other hand, in vivo passive targeting showed preferential accumulation of NPs at tumor sites only within 2 h of their injection, ascribed to the enhanced permeation and retention effect of the tumor. A biodistribution study employing the harvested organs of mice, post-24 h injection of NPs, quantified active targeting as nearly twice as efficient as passive targeting. These outcomes provide potential opportunities for noninvasive diagnosis using NaDyF4-NaGdF4 core-shell NPs for target-specific MRI.

Název v anglickém jazyce

Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles

Popis výsledku anglicky

We illustrate the development of NaDyF4-NaGdF4 core-shell nanoparticles (NPs) for targeting prostate cancer cells using a preclinical 9.4 T magnetic resonance imaging (MRI) of live animals. The NPs composed of paramagnetic Dy3+ and Gd3+ (T-2- and T-1-contrast agents, respectively) demonstrate proton relaxivities of r(1) = 20.2 mM(-1) s(-1) and r(2) = 32.3 mM(-1) s(-1) at clinical 3 T and r(1) = 9.4 mM(-1) s(-1) and r(2) = 144.7 mM(-1) s(-1) at preclinical 9.4 T. The corresponding relaxivity values per NP are r(1) = 19.4 x 105 mM(NP)(-1) s(-1) and r(2) = 33.0 x 10(5) mMNP(-1) s(-1) at 3 T and r(1) = 9.0 x 105 mM(NP)(-1) s(-1) and r(2) = 147.0 x 10(5) mM(NP)(-1) s(-1) at 9.4 T. In vivo active targeting of human prostate tumors grown in nude mice revealed docking of anti-prostate-specific membrane antigen (PSMA) antibody-tagged NPs at tumor sites post-24 h of their intravenous injection. On the other hand, in vivo passive targeting showed preferential accumulation of NPs at tumor sites only within 2 h of their injection, ascribed to the enhanced permeation and retention effect of the tumor. A biodistribution study employing the harvested organs of mice, post-24 h injection of NPs, quantified active targeting as nearly twice as efficient as passive targeting. These outcomes provide potential opportunities for noninvasive diagnosis using NaDyF4-NaGdF4 core-shell NPs for target-specific MRI.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/LM2018129" target="_blank" >LM2018129: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS APPLIED MATERIALS &amp; INTERFACES

ISSN

1944-8244

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

24345-24355

Kód UT WoS článku

000659315800001

EID výsledku v databázi Scopus

2-s2.0-85107711501