Colloidally Stable Monodisperse Fe Nanoparticles as T-2 Contrast Agents for High-Field Clinical and Preclinical Magnetic Resonance Imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00124303" target="_blank" >RIV/00216224:14740/21:00124303 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsanm.0c02848" target="_blank" >https://pubs.acs.org/doi/10.1021/acsanm.0c02848</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.0c02848" target="_blank" >10.1021/acsanm.0c02848</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Colloidally Stable Monodisperse Fe Nanoparticles as T-2 Contrast Agents for High-Field Clinical and Preclinical Magnetic Resonance Imaging

Popis výsledku v původním jazyce

Iron nanoparticles (Fe NPs) produce negative contrast in magnetic resonance imaging (MRI) by shortening the transverse relaxation time (T-2) of water protons at tissue sites. The high sensitivity of Fe toward oxidation under ambient conditions has challenged and impeded the development of stable Fe NPs for bioapplications compared to iron oxide nanoparticles (IONPs). This article demonstrates the synthesis of three batches of fairly monodisperse (size dispersion, &lt;10%), colloidal Fe NPs with inorganic core diameters of 15.2, 12.0, and 8.8 nm. The 15.2 nm Fe NPs show high stability against oxidation, beyond 5 months, when dispersed in chloroform and deionized water. Upon dispersion in deionized water, these NPs gradually develop an amorphous iron oxide shell. On the contrary, upon transfer into water, the smaller Fe NPs oxidize to amorphous iron oxide eventually. The 15.2 nm Fe NPs exhibit much stronger shortening of the T-2 relaxation time compared to the 12.0 and 8.8 nm Fe NPs at both high-field clinical 3 T and preclinical 9.4 T. The transverse relaxivity (r(2)) values of the 15.2 nm Fe NPs, based on per Fe ion concentration, were determined to be 167.9 mM(-1) s(-1) at 3 T and 236.4 mM(-1) s(-1) (higher than similarly sized IONPs) at 9.4 T. The respective r(2)/r(1) ratios of 280 and 788 are high for a T-2 contrast agent, although comprehensive MRI data for Fe NPs are not available in the literature for direct comparison. Fe NPs are promising MRI contrast agents for medical imaging.

Název v anglickém jazyce

Colloidally Stable Monodisperse Fe Nanoparticles as T-2 Contrast Agents for High-Field Clinical and Preclinical Magnetic Resonance Imaging

Popis výsledku anglicky

Iron nanoparticles (Fe NPs) produce negative contrast in magnetic resonance imaging (MRI) by shortening the transverse relaxation time (T-2) of water protons at tissue sites. The high sensitivity of Fe toward oxidation under ambient conditions has challenged and impeded the development of stable Fe NPs for bioapplications compared to iron oxide nanoparticles (IONPs). This article demonstrates the synthesis of three batches of fairly monodisperse (size dispersion, &lt;10%), colloidal Fe NPs with inorganic core diameters of 15.2, 12.0, and 8.8 nm. The 15.2 nm Fe NPs show high stability against oxidation, beyond 5 months, when dispersed in chloroform and deionized water. Upon dispersion in deionized water, these NPs gradually develop an amorphous iron oxide shell. On the contrary, upon transfer into water, the smaller Fe NPs oxidize to amorphous iron oxide eventually. The 15.2 nm Fe NPs exhibit much stronger shortening of the T-2 relaxation time compared to the 12.0 and 8.8 nm Fe NPs at both high-field clinical 3 T and preclinical 9.4 T. The transverse relaxivity (r(2)) values of the 15.2 nm Fe NPs, based on per Fe ion concentration, were determined to be 167.9 mM(-1) s(-1) at 3 T and 236.4 mM(-1) s(-1) (higher than similarly sized IONPs) at 9.4 T. The respective r(2)/r(1) ratios of 280 and 788 are high for a T-2 contrast agent, although comprehensive MRI data for Fe NPs are not available in the literature for direct comparison. Fe NPs are promising MRI contrast agents for medical imaging.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

<a href="/cs/project/LM2018129" target="_blank" >LM2018129: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1235-1242

Kód UT WoS článku

000624546800032

EID výsledku v databázi Scopus

2-s2.0-85100626812