Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated epsilon-Fe2O3

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077749" target="_blank" >RIV/00023001:_____/19:00077749 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/20:43919643

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S0304885319302355?token=D6AB1438B77D9405926D5A0B231F6E121B3DDAA8D57AB31EE9B0F27D2A7A647C7BFDB583499BEC6245909A69FD3FBFE9" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0304885319302355?token=D6AB1438B77D9405926D5A0B231F6E121B3DDAA8D57AB31EE9B0F27D2A7A647C7BFDB583499BEC6245909A69FD3FBFE9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmmm.2019.02.067" target="_blank" >10.1016/j.jmmm.2019.02.067</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated epsilon-Fe2O3

Popis výsledku v původním jazyce

Magnetic nanoparticles of iron oxides have received extensive attention in the biomedical research, e.g. as prospective contrast agents for T-2-weighted magnetic resonance imaging (MRI). The ability of a contrast agent to enhance the relaxation rate of H-1 nuclei in its vicinity is quantitatively described by its relaxivity. Among the polymorphs of the iron(III) oxide, the nanoparticulate epsilon-Fe2O3, distinguished by its high magnetocrystalline anisotropy resulting in a blocked state of single-domain particles up to the Curie temperature of similar to 500 K, has never been studied as a contrast agent for MRI before. We analyzed r(1) and r(2) relaxivities of epsilon-Fe(2)O(3 )nanoparticles coated with amorphous silica, particularly with the aim to determine their dependences on the external magnetic field, temperature, and thickness of the silica coating. The r(2) relaxivity was interpreted within the motional averaging and static dephasing regimes. MRI images at 11.75 T confirmed high applicability of epsilon-Fe2O3-based contrast agents in ultra-high fields. We present the first case study considering epsilon-Fe2O3 nanomagnets for prospective application in biomedicine, in particular for MRI in ultra-high fields. The study is complemented by a thorough investigation of magnetic properties of the nanoparticles, revealing some interesting anomalies.

Název v anglickém jazyce

Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated epsilon-Fe2O3

Popis výsledku anglicky

Magnetic nanoparticles of iron oxides have received extensive attention in the biomedical research, e.g. as prospective contrast agents for T-2-weighted magnetic resonance imaging (MRI). The ability of a contrast agent to enhance the relaxation rate of H-1 nuclei in its vicinity is quantitatively described by its relaxivity. Among the polymorphs of the iron(III) oxide, the nanoparticulate epsilon-Fe2O3, distinguished by its high magnetocrystalline anisotropy resulting in a blocked state of single-domain particles up to the Curie temperature of similar to 500 K, has never been studied as a contrast agent for MRI before. We analyzed r(1) and r(2) relaxivities of epsilon-Fe(2)O(3 )nanoparticles coated with amorphous silica, particularly with the aim to determine their dependences on the external magnetic field, temperature, and thickness of the silica coating. The r(2) relaxivity was interpreted within the motional averaging and static dephasing regimes. MRI images at 11.75 T confirmed high applicability of epsilon-Fe2O3-based contrast agents in ultra-high fields. We present the first case study considering epsilon-Fe2O3 nanomagnets for prospective application in biomedicine, in particular for MRI in ultra-high fields. The study is complemented by a thorough investigation of magnetic properties of the nanoparticles, revealing some interesting anomalies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/GA16-04340S" target="_blank" >GA16-04340S: Oxidové nanomagnety, jejich vlastnosti a interakce s biologickými systémy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of magnetism and magnetic materials

ISSN

0304-8853

e-ISSN

—

Svazek periodika

480

Číslo periodika v rámci svazku

June 15

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

154-163

Kód UT WoS článku

000460508900021

EID výsledku v databázi Scopus

2-s2.0-85062147368