Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated epsilon-Fe2O3

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F20%3A43919643" target="_blank" >RIV/60461373:22340/20:43919643 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/19:00077749

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0304885319302355" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304885319302355</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmmm.2019.02.067" target="_blank" >10.1016/j.jmmm.2019.02.067</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated epsilon-Fe2O3

Popis výsledku v původním jazyce

Magnetic nanoparticles of iron oxides have received extensive attention in the biomedical research, e.g. as prospective contrast agents for T-2-weighted magnetic resonance imaging (MRI). The ability of a contrast agent to enhance the relaxation rate of H-1 nuclei in its vicinity is quantitatively described by its relaxivity. Among the polymorphs of the iron(III) oxide, the nanoparticulate epsilon-Fe2O3, distinguished by its high magnetocrystalline anisotropy resulting in a blocked state of single-domain particles up to the Curie temperature of similar to 500 K, has never been studied as a contrast agent for MRI before. We analyzed r(1) and r(2) relaxivities of epsilon-Fe2O3 nanoparticles coated with amorphous silica, particularly with the aim to determine their dependences on the external magnetic field, temperature, and thickness of the silica coating. The r(2) relaxivity was interpreted within the motional averaging and static dephasing regimes. MRI images at 11.75 T confirmed high applicability of epsilon-Fe2O3-based contrast agents in ultra-high fields.

Název v anglickém jazyce

Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated epsilon-Fe2O3

Popis výsledku anglicky

Magnetic nanoparticles of iron oxides have received extensive attention in the biomedical research, e.g. as prospective contrast agents for T-2-weighted magnetic resonance imaging (MRI). The ability of a contrast agent to enhance the relaxation rate of H-1 nuclei in its vicinity is quantitatively described by its relaxivity. Among the polymorphs of the iron(III) oxide, the nanoparticulate epsilon-Fe2O3, distinguished by its high magnetocrystalline anisotropy resulting in a blocked state of single-domain particles up to the Curie temperature of similar to 500 K, has never been studied as a contrast agent for MRI before. We analyzed r(1) and r(2) relaxivities of epsilon-Fe2O3 nanoparticles coated with amorphous silica, particularly with the aim to determine their dependences on the external magnetic field, temperature, and thickness of the silica coating. The r(2) relaxivity was interpreted within the motional averaging and static dephasing regimes. MRI images at 11.75 T confirmed high applicability of epsilon-Fe2O3-based contrast agents in ultra-high fields.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Magnetism and Magnetic Materiale

ISSN

0304-8853

e-ISSN

—

Svazek periodika

480

Číslo periodika v rámci svazku

JUN 15 2019

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

154-163

Kód UT WoS článku

000460508900021

EID výsledku v databázi Scopus

2-s2.0-85062147368