Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated ε-Fe2O3

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F19%3A10391997" target="_blank" >RIV/00216208:11320/19:10391997 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/19:00519491 RIV/00216208:11110/19:10391997

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j0Ey6RuChD" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j0Ey6RuChD</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmmm.2019.02.067" target="_blank" >10.1016/j.jmmm.2019.02.067</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated ε-Fe2O3

Popis výsledku v původním jazyce

Magnetic nanoparticles of iron oxides have received extensive attention in the biomedical research, e.g. as prospective contrast agents for T2-weighted magnetic resonance imaging (MRI). The ability of a contrast agent to enhance the relaxation rate of 1H nuclei in its vicinity is quantitatively described by its relaxivity. Among the polymorphs of the iron(III) oxide, the nanoparticulate ε-Fe2O3, distinguished by its high magnetocrystalline anisotropy resulting in a blocked state of single-domain particles up to the Curie temperature of ~500 K, has never been studied as a contrast agent for MRI before. We analyzed r1 and r2 relaxivities of ε-Fe2O3 nanoparticles coated with amorphous silica, particularly with the aim to determine their dependences on the external magnetic field, temperature, and thickness of the silica coating. The r2 relaxivity was interpreted within the motional averaging and static dephasing regimes. MRI images at 11.75 T confirmed high applicability of ε-Fe2O3-based contrast agents in ultra-high fields. We present the first case study considering ε-Fe2O3 nanomagnets for prospective application in biomedicine, in particular for MRI in ultra-high fields. The study is complemented by a thorough investigation of magnetic properties of the nanoparticles, revealing some interesting anomalies.

Název v anglickém jazyce

Nanomagnets for ultra-high field MRI: Magnetic properties and transverse relaxivity of silica-coated ε-Fe2O3

Popis výsledku anglicky

Magnetic nanoparticles of iron oxides have received extensive attention in the biomedical research, e.g. as prospective contrast agents for T2-weighted magnetic resonance imaging (MRI). The ability of a contrast agent to enhance the relaxation rate of 1H nuclei in its vicinity is quantitatively described by its relaxivity. Among the polymorphs of the iron(III) oxide, the nanoparticulate ε-Fe2O3, distinguished by its high magnetocrystalline anisotropy resulting in a blocked state of single-domain particles up to the Curie temperature of ~500 K, has never been studied as a contrast agent for MRI before. We analyzed r1 and r2 relaxivities of ε-Fe2O3 nanoparticles coated with amorphous silica, particularly with the aim to determine their dependences on the external magnetic field, temperature, and thickness of the silica coating. The r2 relaxivity was interpreted within the motional averaging and static dephasing regimes. MRI images at 11.75 T confirmed high applicability of ε-Fe2O3-based contrast agents in ultra-high fields. We present the first case study considering ε-Fe2O3 nanomagnets for prospective application in biomedicine, in particular for MRI in ultra-high fields. The study is complemented by a thorough investigation of magnetic properties of the nanoparticles, revealing some interesting anomalies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Magnetism and Magnetic Materials

ISSN

0304-8853

e-ISSN

—

Svazek periodika

480

Číslo periodika v rámci svazku

February 2019

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

154-163

Kód UT WoS článku

000460508900021

EID výsledku v databázi Scopus

2-s2.0-85062147368