Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00132847" target="_blank" >RIV/00216224:14740/23:00132847 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ceitec.eu/ceitec-postdoc-phd-retreat/a4548" target="_blank" >https://www.ceitec.eu/ceitec-postdoc-phd-retreat/a4548</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.

Popis výsledku v původním jazyce

Protein p53 has a central role in tumor suppression. Under normal conditions, p53 levels are kept low, but in response to DNA damage, p53 becomes stabilized and initiates the transcription of its target genes. In chronic lymphocytic leukemia (CLL), aberrations in the TP53 gene are associated with the aggressive disease since the function of p53 protein is impaired. However, the p53 function might also be disrupted by other mechanisms, e.g. altered phosphorylation, even in the wild-type protein. Therefore, we aimed to investigate the impact of p53 phosphorylation on p53 function in CLL and uncover what underlies the existence of possible different phosphorylation patterns.

Název v anglickém jazyce

Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.

Popis výsledku anglicky

Protein p53 has a central role in tumor suppression. Under normal conditions, p53 levels are kept low, but in response to DNA damage, p53 becomes stabilized and initiates the transcription of its target genes. In chronic lymphocytic leukemia (CLL), aberrations in the TP53 gene are associated with the aggressive disease since the function of p53 protein is impaired. However, the p53 function might also be disrupted by other mechanisms, e.g. altered phosphorylation, even in the wild-type protein. Therefore, we aimed to investigate the impact of p53 phosphorylation on p53 function in CLL and uncover what underlies the existence of possible different phosphorylation patterns.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LX22NPO5102" target="_blank" >LX22NPO5102: Národní ústav pro výzkum rakoviny</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů