Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00135359" target="_blank" >RIV/00216224:14740/24:00135359 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.jpclett.3c02785" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jpclett.3c02785</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jpclett.3c02785" target="_blank" >10.1021/acs.jpclett.3c02785</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes

Popis výsledku v původním jazyce

Curvature sensing is an essential ability of biomolecules to preferentially localize to membrane regions of a specific curvature. It has been shown that amphipathic helices(AHs),helical peptides with both hydrophilic and hydrophobic regions,could sense a positive membrane curvature.The origin of this AH sensing has been attributed to their ability to exploit lipid-packing defects that are enhanced in regions of positive curvature. In this study,we revisit an alternative framework where AHs act as sensors of local internal stress within the membrane,suggesting the possibility of an AH sensing a negative membrane curvature. Using molecular dynamics simulations, we gradually tuned the hydrophobicity of AHs, thereby adjusting their insertion depth so that the curvature preference of AHs is switched from positive to negative. This study suggests that highly hydrophobic AHs could preferentially localize proteins to regions of a negative membrane curvature.

Název v anglickém jazyce

Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes

Popis výsledku anglicky

Curvature sensing is an essential ability of biomolecules to preferentially localize to membrane regions of a specific curvature. It has been shown that amphipathic helices(AHs),helical peptides with both hydrophilic and hydrophobic regions,could sense a positive membrane curvature.The origin of this AH sensing has been attributed to their ability to exploit lipid-packing defects that are enhanced in regions of positive curvature. In this study,we revisit an alternative framework where AHs act as sensors of local internal stress within the membrane,suggesting the possibility of an AH sensing a negative membrane curvature. Using molecular dynamics simulations, we gradually tuned the hydrophobicity of AHs, thereby adjusting their insertion depth so that the curvature preference of AHs is switched from positive to negative. This study suggests that highly hydrophobic AHs could preferentially localize proteins to regions of a negative membrane curvature.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of physical chemistry letters

ISSN

1948-7185

e-ISSN

1948-7185

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

175-179

Kód UT WoS článku

001141731800001

EID výsledku v databázi Scopus

2-s2.0-85181802800