Kinetika a mechanismus desulfurizační reakce 1-methyl-2-fenylchinazolin-4(1H)-thionů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F04%3A00001384" target="_blank" >RIV/00216275:25310/04:00001384 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Kinetics and mechanism of desulfurization reaction of 1-methyl-2-phenylquinazoline-4(1H)-thiones

Popis výsledku v původním jazyce

Kinetics and mechanism of desulfurization reaction of 1-methyl-2-(subst. phenyl)quinazoline-4(1H)-thiones in sodium methoxide solutions have been studied, giving the corresponding 1-methyl-2-(subst. phenyl)quinazoline-4(1H)-ones. The reaction proceeds intwo steps. The first step involves splitting off of sulfur in the form of SH- and is much faster than the second step, whose rate is almost independent of the concentration of water in methanol. At lowest concentrations of methoxide, the rate of the first step increases linearly, but at higher concentrations a gradual decrease in the rate takes place. The rate of the second step, i.e. the transformation of the intermediate formed (In) into 1-methyl-2-(subst. phenyl)quinazolin-4(1H)-one (2a-e), is independent of the methoxide concentration but increases with increasing concentration of water in methanol. On the basis of the kinetic dependences, the mechanism for both steps of the desulfurization and the structure of intermediate In were

Název v anglickém jazyce

Kinetics and mechanism of desulfurization reaction of 1-methyl-2-phenylquinazoline-4(1H)-thiones

Popis výsledku anglicky

Kinetics and mechanism of desulfurization reaction of 1-methyl-2-(subst. phenyl)quinazoline-4(1H)-thiones in sodium methoxide solutions have been studied, giving the corresponding 1-methyl-2-(subst. phenyl)quinazoline-4(1H)-ones. The reaction proceeds intwo steps. The first step involves splitting off of sulfur in the form of SH- and is much faster than the second step, whose rate is almost independent of the concentration of water in methanol. At lowest concentrations of methoxide, the rate of the first step increases linearly, but at higher concentrations a gradual decrease in the rate takes place. The rate of the second step, i.e. the transformation of the intermediate formed (In) into 1-methyl-2-(subst. phenyl)quinazolin-4(1H)-one (2a-e), is independent of the methoxide concentration but increases with increasing concentration of water in methanol. On the basis of the kinetic dependences, the mechanism for both steps of the desulfurization and the structure of intermediate In were

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Collection of Czechoslovak Chemical Communications

ISSN

0010-0765

e-ISSN

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Svazek periodika

69

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

2212-2222

Kód UT WoS článku

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EID výsledku v databázi Scopus

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