Microfluidic system with integrated magnetic carrier for immunoprecipitation of Abeta peptides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F09%3A00008575" target="_blank" >RIV/00216275:25310/09:00008575 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Microfluidic system with integrated magnetic carrier for immunoprecipitation of Abeta peptides

Popis výsledku v původním jazyce

Alzheimer disease (AD) is the most prevalent cause of dementia in the elderly population today with an increasing tendency. In spite of the fact that it is so common, AD often goes unrecognized or is misdiagnosed in its early stages. The importance of the early and accurate diagnosis is evident. Development of valuable diagnostic methods for determination of AD specific biomarkers, such as Abeta peptides and Tau protein, is one of the current goals. The aim of this study is integration of immunomagneticcarrier with orientedly immobilized anti-A? antibody into microfluidic device and an application of this system for immunoprecipitation of Abeta peptides. Binding efficiency and specificity of the immunosorbent were validated by serum or cerebrospinal fluid spiked with synthetic Abeta peptides.

Název v anglickém jazyce

Microfluidic system with integrated magnetic carrier for immunoprecipitation of Abeta peptides

Popis výsledku anglicky

Alzheimer disease (AD) is the most prevalent cause of dementia in the elderly population today with an increasing tendency. In spite of the fact that it is so common, AD often goes unrecognized or is misdiagnosed in its early stages. The importance of the early and accurate diagnosis is evident. Development of valuable diagnostic methods for determination of AD specific biomarkers, such as Abeta peptides and Tau protein, is one of the current goals. The aim of this study is integration of immunomagneticcarrier with orientedly immobilized anti-A? antibody into microfluidic device and an application of this system for immunoprecipitation of Abeta peptides. Binding efficiency and specificity of the immunosorbent were validated by serum or cerebrospinal fluid spiked with synthetic Abeta peptides.

Druh

D - Stať ve sborníku

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

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Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2009

ISBN

978-88-7587-528-2

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

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Název nakladatele

MEDIMOND s.r.l.

Místo vydání

Pianoro

Místo konání akce

Praha

Datum konání akce

15. 3. 2009

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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