Relationships between Hepatic Stearoyl-CoA Desaturase 1 activity and mRNA Expression with Liver Fat content in Humans
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39892033" target="_blank" >RIV/00216275:25310/11:39892033 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1152/ajpendo.00306.2010" target="_blank" >http://dx.doi.org/10.1152/ajpendo.00306.2010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/ajpendo.00306.2010" target="_blank" >10.1152/ajpendo.00306.2010</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Relationships between Hepatic Stearoyl-CoA Desaturase 1 activity and mRNA Expression with Liver Fat content in Humans
Popis výsledku v původním jazyce
Stearoyl-CoA desaturase-1 (SCD1) has gained much interest as a future drug target to treat fatty liver and its consequences. However, there are few and inconsistent human data about expression and activity of this important enzyme. We investigated activity and expression of SCD1 and their relationships with liver fat (LF) content in human liver samples. Fifty subjects undergoing liver surgery were studied. SCD1 activity was estimated from the ratio of oleate (C18:1) to stearate (C18:0) within lipid subfractions. Furthermore, SCD1 mRNA expression and LF content were measured. Similarly to previous studies, we observed a strong positive correlation between LF content and the C18:1/C18:0 ratio in the combined fatty acid (FA) fractions (r = 0.96, P { 0.0001), which could be interpreted as higher SCD1 activity with increasing LF. However, hepatic SCD1 mRNA expression did not correlate with LF (r = 0.16, P = 0.13). To solve these conflicting data, we analyzed the FA composition of hepatic li
Název v anglickém jazyce
Relationships between Hepatic Stearoyl-CoA Desaturase 1 activity and mRNA Expression with Liver Fat content in Humans
Popis výsledku anglicky
Stearoyl-CoA desaturase-1 (SCD1) has gained much interest as a future drug target to treat fatty liver and its consequences. However, there are few and inconsistent human data about expression and activity of this important enzyme. We investigated activity and expression of SCD1 and their relationships with liver fat (LF) content in human liver samples. Fifty subjects undergoing liver surgery were studied. SCD1 activity was estimated from the ratio of oleate (C18:1) to stearate (C18:0) within lipid subfractions. Furthermore, SCD1 mRNA expression and LF content were measured. Similarly to previous studies, we observed a strong positive correlation between LF content and the C18:1/C18:0 ratio in the combined fatty acid (FA) fractions (r = 0.96, P { 0.0001), which could be interpreted as higher SCD1 activity with increasing LF. However, hepatic SCD1 mRNA expression did not correlate with LF (r = 0.16, P = 0.13). To solve these conflicting data, we analyzed the FA composition of hepatic li
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
American Journal of Physiology: Endocrinology and Metabolism
ISSN
0193-1849
e-ISSN
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Svazek periodika
300
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
6
Strana od-do
321-326
Kód UT WoS článku
000289011600008
EID výsledku v databázi Scopus
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