High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895013" target="_blank" >RIV/00216275:25310/12:39895013 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1210/jc.2012-2152" target="_blank" >http://dx.doi.org/10.1210/jc.2012-2152</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/jc.2012-2152" target="_blank" >10.1210/jc.2012-2152</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet

Popis výsledku v původním jazyce

Context: Increased hepatic de novo lipogenesis(DNL) in response to dietary sugar is implicated in the pathology of fatty liver. Saturated fatty acids are the product of DNL and exert lipotoxic effects that promote liver fat accumulation. Desaturation offatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Here we investigated whether DNL and SCD1 are activated in parallel by dietary sugar and influence liver fat accumulation. Methods: In 20 healthy subjects (eight females and 12 males, aged 30.5 +/- 2.0 yr, body mass index 25.9 +/- 0.5 kg/m2) who received a 4-wk lipogenic diet supplemented with 150 g/d of monosaccharides, hepatic SCD1 activity a DNL were determined using validated fatty acid ratios (16:1n-7/16:0; 16:0/18:2n-6) in very low-density lipoprotein triglycerides. Liver fat content was measured by localized 1H-magnetic resonance spectroscopy. Results: At baseline, liver fat content was positively associated with the DNL (r=0.54, P=0.01) but no

Název v anglickém jazyce

High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet

Popis výsledku anglicky

Context: Increased hepatic de novo lipogenesis(DNL) in response to dietary sugar is implicated in the pathology of fatty liver. Saturated fatty acids are the product of DNL and exert lipotoxic effects that promote liver fat accumulation. Desaturation offatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Here we investigated whether DNL and SCD1 are activated in parallel by dietary sugar and influence liver fat accumulation. Methods: In 20 healthy subjects (eight females and 12 males, aged 30.5 +/- 2.0 yr, body mass index 25.9 +/- 0.5 kg/m2) who received a 4-wk lipogenic diet supplemented with 150 g/d of monosaccharides, hepatic SCD1 activity a DNL were determined using validated fatty acid ratios (16:1n-7/16:0; 16:0/18:2n-6) in very low-density lipoprotein triglycerides. Liver fat content was measured by localized 1H-magnetic resonance spectroscopy. Results: At baseline, liver fat content was positively associated with the DNL (r=0.54, P=0.01) but no

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Endocrinology and Metabolism

ISSN

0021-972X

e-ISSN

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Svazek periodika

97

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

"E2288"-"E2292"

Kód UT WoS článku

000312003900012

EID výsledku v databázi Scopus

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