Voltammetric determination of leucovorin using silver solid amalgam electrode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895237" target="_blank" >RIV/00216275:25310/12:39895237 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/12:00375916

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.electacta.2011.11.071" target="_blank" >http://dx.doi.org/10.1016/j.electacta.2011.11.071</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.electacta.2011.11.071" target="_blank" >10.1016/j.electacta.2011.11.071</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetric determination of leucovorin using silver solid amalgam electrode

Popis výsledku v původním jazyce

The voltammetric behavior of leucovorin (LV), as an important and stable reduced metabolite of folic acid, has been investigated on polished (p-AgSAE) and mercury meniscus modified (m-AgSAE) silver solid amalgam electrodes in this paper. LV, after its reverse electrochemical oxidation, can be reduced in two reduction steps in an acidic medium on both electrodes used. The first reduction peak (E-p = -400 mV) can be used for determination of LV. Differential Pulse Voltammetry (DPV) was applied for monitoring voltammetric behavior of LV on both working electrodes. Elimination voltammetry with linear scan was applied for elucidation of the reaction mechanisms. The limits of detection were calculated as 2.2 x 10(-8) mol L-1 (t(acc) = 60 s) for m-AgSAE and 5.0 x 10(-8) mol L-1 (t(acc) = 100 s) for p-AgSAE. The proposed method was applied for LV determination in the pharmaceutical preparation which has been commonly used during methotrexate therapy. (C) 2011 Published by Elsevier Ltd.

Název v anglickém jazyce

Voltammetric determination of leucovorin using silver solid amalgam electrode

Popis výsledku anglicky

The voltammetric behavior of leucovorin (LV), as an important and stable reduced metabolite of folic acid, has been investigated on polished (p-AgSAE) and mercury meniscus modified (m-AgSAE) silver solid amalgam electrodes in this paper. LV, after its reverse electrochemical oxidation, can be reduced in two reduction steps in an acidic medium on both electrodes used. The first reduction peak (E-p = -400 mV) can be used for determination of LV. Differential Pulse Voltammetry (DPV) was applied for monitoring voltammetric behavior of LV on both working electrodes. Elimination voltammetry with linear scan was applied for elucidation of the reaction mechanisms. The limits of detection were calculated as 2.2 x 10(-8) mol L-1 (t(acc) = 60 s) for m-AgSAE and 5.0 x 10(-8) mol L-1 (t(acc) = 100 s) for p-AgSAE. The proposed method was applied for LV determination in the pharmaceutical preparation which has been commonly used during methotrexate therapy. (C) 2011 Published by Elsevier Ltd.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electrochimica Acta

ISSN

0013-4686

e-ISSN

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Svazek periodika

60

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

375-383

Kód UT WoS článku

000300142100052

EID výsledku v databázi Scopus

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