Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895562" target="_blank" >RIV/00216275:25310/12:39895562 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/12:10124795

Výsledek na webu

<a href="http://dx.doi.org/10.1002/aoc.2845" target="_blank" >http://dx.doi.org/10.1002/aoc.2845</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/aoc.2845" target="_blank" >10.1002/aoc.2845</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands

Popis výsledku v původním jazyce

The intramolecularly coordinated phosphine and stibine ligands L1PPh2 (1), L2PPh2 (2) and L2SbPh2 (3) containing Y,C,Y-chelating ligands, L1?=?2,6-(tBuOCH2)2C6H4- and L2?=?2,6-(Me2NCH2)2C6H4-, were prepared and characterized. The treatment of these ligands 13 with PtCl2 yielded complexes trans-{[2,6-(tBuOCH2)2C6H3]PPh2}2PtCl2 (4), cis-{[2,6-(Me2NCH2)2C6H3]PPh2}PtCl2 (5), and cis-{[2,6-(Me2NCH2)2C6H3]SbPh2}PtCl2 (6) as the result of different ability of the starting compounds 13 to complex platinum centre. Compounds 16 were characterized by 1H, 13C and 31P NMR spectroscopy and electrospray ionization mass spectrometry, and molecular structures of 36 were determined by X-ray diffraction analysis. The substitution reactions of complexes 46 were also studied. The reaction of 5 and 6 with NaI yielded complexes {[2,6-(Me2NCH2)2C6H3]PPh2}PtI2 (7) and {[2,6-(Me2NCH2)2C6H3]SbPh2}PtI2 (8), while the same reaction of 4 with NaI did not proceed. As the compounds 7 and 8 structurally resemble cispl

Název v anglickém jazyce

Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands

Popis výsledku anglicky

The intramolecularly coordinated phosphine and stibine ligands L1PPh2 (1), L2PPh2 (2) and L2SbPh2 (3) containing Y,C,Y-chelating ligands, L1?=?2,6-(tBuOCH2)2C6H4- and L2?=?2,6-(Me2NCH2)2C6H4-, were prepared and characterized. The treatment of these ligands 13 with PtCl2 yielded complexes trans-{[2,6-(tBuOCH2)2C6H3]PPh2}2PtCl2 (4), cis-{[2,6-(Me2NCH2)2C6H3]PPh2}PtCl2 (5), and cis-{[2,6-(Me2NCH2)2C6H3]SbPh2}PtCl2 (6) as the result of different ability of the starting compounds 13 to complex platinum centre. Compounds 16 were characterized by 1H, 13C and 31P NMR spectroscopy and electrospray ionization mass spectrometry, and molecular structures of 36 were determined by X-ray diffraction analysis. The substitution reactions of complexes 46 were also studied. The reaction of 5 and 6 with NaI yielded complexes {[2,6-(Me2NCH2)2C6H3]PPh2}PtI2 (7) and {[2,6-(Me2NCH2)2C6H3]SbPh2}PtI2 (8), while the same reaction of 4 with NaI did not proceed. As the compounds 7 and 8 structurally resemble cispl

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP207%2F10%2F0215" target="_blank" >GAP207/10/0215: Struktura, vlastnosti a využití C,N-, a Y,C,Y-chelatovaných organokovových sloučenin a podobných komplexů kovů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Organometallic Chemistry

ISSN

0268-2605

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

237-245

Kód UT WoS článku

000303042800006

EID výsledku v databázi Scopus

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