Antibacterial and Herbicidal Activity of Ring-Substituted 2-Hydroxynaphthalene-1-carboxanilides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896488" target="_blank" >RIV/00216275:25310/13:39896488 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/13:43872231 RIV/62157124:16370/13:43872231 RIV/62157124:16810/13:43872231

Výsledek na webu

<a href="http://dx.doi.org/10.3390/molecules18089397" target="_blank" >http://dx.doi.org/10.3390/molecules18089397</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules18089397" target="_blank" >10.3390/molecules18089397</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antibacterial and Herbicidal Activity of Ring-Substituted 2-Hydroxynaphthalene-1-carboxanilides

Popis výsledku v původním jazyce

In this study, a series of twenty-two ring-substituted 2-hydroxynaphthalene1-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistantS. aureus strains, Mycobacterium marinum, M. kasasii, M. smegmatis and M. avium paratuberculosis. The compounds were also tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. 2-Hydroxy-N-phenylnaphthalene-1-carboxanilide and 2-hydroxy-N-(3trifluoromethylphenyl)naphthalene-1-carboxamide showed MIC = 26.0 ?mol/L against methicillin-resistant S. aureus and (IC50 = 29 ?mol/L) were the most active PET inhibitors. Some of tested compounds showed the antibacterial and antimycobacterial activity against the tested strains comparable or higher than the standards ampicillin or isoniazid. Thus, for example, 2-hydroxy-N-(3-nitrophenyl)naphthalene-1carboxamide show

Název v anglickém jazyce

Antibacterial and Herbicidal Activity of Ring-Substituted 2-Hydroxynaphthalene-1-carboxanilides

Popis výsledku anglicky

In this study, a series of twenty-two ring-substituted 2-hydroxynaphthalene1-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistantS. aureus strains, Mycobacterium marinum, M. kasasii, M. smegmatis and M. avium paratuberculosis. The compounds were also tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. 2-Hydroxy-N-phenylnaphthalene-1-carboxanilide and 2-hydroxy-N-(3trifluoromethylphenyl)naphthalene-1-carboxamide showed MIC = 26.0 ?mol/L against methicillin-resistant S. aureus and (IC50 = 29 ?mol/L) were the most active PET inhibitors. Some of tested compounds showed the antibacterial and antimycobacterial activity against the tested strains comparable or higher than the standards ampicillin or isoniazid. Thus, for example, 2-hydroxy-N-(3-nitrophenyl)naphthalene-1carboxamide show

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecules

ISSN

1420-3049

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

23

Strana od-do

9397-9419

Kód UT WoS článku

000330304100044

EID výsledku v databázi Scopus

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