Electrochemical mechanism and sensitive assay of antiretroviral drug Abacavir in biological sample using multiwalled carbon nanotube modified pyrolytic graphite electrode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898285" target="_blank" >RIV/00216275:25310/14:39898285 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jelechem.2013.11.012" target="_blank" >http://dx.doi.org/10.1016/j.jelechem.2013.11.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelechem.2013.11.012" target="_blank" >10.1016/j.jelechem.2013.11.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical mechanism and sensitive assay of antiretroviral drug Abacavir in biological sample using multiwalled carbon nanotube modified pyrolytic graphite electrode

Popis výsledku v původním jazyce

Multiwalled carbon nanotube modified edge plane pyrolytic graphite electrode (MWCNT/EPPGE) was developed and implemented for the determination of antiretroviral drug Abacavir using differential pulse adsorptive stripping voltammetry (DP AdSV). Cyclic voltammogram showed two oxidation peaks located at +0.91 V and +1.10 V on (MWCNT/EPPGE). Dependency of peak potential and peak current on pH was investigated as details. The oxidation potentials affected by the pH indicating protons are involved in the electrochemical oxidation of Abacavir. Mass transport to the electrode surface was found as a combination of diffusion and adsorption which was concluded by studying the potential scan rate dependency of both peak currents. The oxidation mechanism was proposed using the obtained data and discussed. A large enhancement in both of the peak currents was observed with applying an accumulation step presenting the effect of adsorption. Peak currents showed a linear relation upon the Abacavir conce

Název v anglickém jazyce

Electrochemical mechanism and sensitive assay of antiretroviral drug Abacavir in biological sample using multiwalled carbon nanotube modified pyrolytic graphite electrode

Popis výsledku anglicky

Multiwalled carbon nanotube modified edge plane pyrolytic graphite electrode (MWCNT/EPPGE) was developed and implemented for the determination of antiretroviral drug Abacavir using differential pulse adsorptive stripping voltammetry (DP AdSV). Cyclic voltammogram showed two oxidation peaks located at +0.91 V and +1.10 V on (MWCNT/EPPGE). Dependency of peak potential and peak current on pH was investigated as details. The oxidation potentials affected by the pH indicating protons are involved in the electrochemical oxidation of Abacavir. Mass transport to the electrode surface was found as a combination of diffusion and adsorption which was concluded by studying the potential scan rate dependency of both peak currents. The oxidation mechanism was proposed using the obtained data and discussed. A large enhancement in both of the peak currents was observed with applying an accumulation step presenting the effect of adsorption. Peak currents showed a linear relation upon the Abacavir conce

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Electroanalytical Chemistry

ISSN

1572-6657

e-ISSN

—

Svazek periodika

712

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

178-184

Kód UT WoS článku

000330749300025

EID výsledku v databázi Scopus

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