Organs of BALB/c mice can be injured in course of tularemia
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898412" target="_blank" >RIV/00216275:25310/14:39898412 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60162694:G44__/14:43875214 RIV/00216305:26620/14:PU127105
Výsledek na webu
<a href="http://biomed.papers.upol.cz/artkey/bio-201404-0010_Organs_of_BALB_c_mice_can_be_injured_in_course_of_tularemia.php#.VK-Z7snz-p4" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201404-0010_Organs_of_BALB_c_mice_can_be_injured_in_course_of_tularemia.php#.VK-Z7snz-p4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2013.006" target="_blank" >10.5507/bp.2013.006</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Organs of BALB/c mice can be injured in course of tularemia
Popis výsledku v původním jazyce
Background: Francisella tularensis is a biological agent exploitable for bioterrorism and biological warfare purposes due to serious pathogenic progression and easy dissemination. Despite intensive research in the past, some adverse consequences remain unclear. One consequence of this pathogen is oxidative stress. Aims: The aim of this study was to undertake ex vivo assays for monitoring the disease in mice and increase our knowledge of the oxidative stress induced by tularemia. Methods: The mouse BALB/c model was chosen and the animals were infected by a dose 104 CFU of F. tularensis. After five days, the animals were euthanized. Blood immediately processed in plasma, spleen and liver were sampled from the cadavers. Oxidative stress markers, cytokinesand histopathological were undertaken. Results: There was a significant link between oxidative stress and tularemia. Particularly elevated levels of malondialdehyde and decreased levels of low molecular weight antioxidants were found in
Název v anglickém jazyce
Organs of BALB/c mice can be injured in course of tularemia
Popis výsledku anglicky
Background: Francisella tularensis is a biological agent exploitable for bioterrorism and biological warfare purposes due to serious pathogenic progression and easy dissemination. Despite intensive research in the past, some adverse consequences remain unclear. One consequence of this pathogen is oxidative stress. Aims: The aim of this study was to undertake ex vivo assays for monitoring the disease in mice and increase our knowledge of the oxidative stress induced by tularemia. Methods: The mouse BALB/c model was chosen and the animals were infected by a dose 104 CFU of F. tularensis. After five days, the animals were euthanized. Blood immediately processed in plasma, spleen and liver were sampled from the cadavers. Oxidative stress markers, cytokinesand histopathological were undertaken. Results: There was a significant link between oxidative stress and tularemia. Particularly elevated levels of malondialdehyde and decreased levels of low molecular weight antioxidants were found in
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EE - Mikrobiologie, virologie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Svazek periodika
158
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
5
Strana od-do
557-561
Kód UT WoS článku
000347173200010
EID výsledku v databázi Scopus
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