PHOTOCATALYTIC OXIDATION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

PHOTOCATALYTIC OXIDATION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Popis výsledku v původním jazyce

Pharmaceuticals diclofenac and naproxen belong to class of non-steroidal anti-inflammatory drugs (NSAIDs). These substances are very often found in outlets of WWTP or in surface waters, because among all classes of pharmaceuticals, they are frequently prescribed and purchased. These substances have by their nature a strong biological effect, so non-target organisms are affected. For example diclofenac causes cytological malformations of liver tissue within a concentration 28 ?g/L (O. mykkis). Sensitive organisms to naproxen are crustaceans, where the EC50 for (C. dubia) is 330 ?g/L, but degradation products of this drug are significantly more toxic. EC50 for degradation products of naproxen to C. dubia are less than 100 ?g/L. Diclofenac and naproxen (500 ?g/L) were from model water samples removed by heterogeneous photocatalysis in 4L batch reactor. After irradiation of the catalyst, the system produces .OH radicals, which causes destruction of the organic substance. As the catalyst used was 0.5 g/L titanium dioxide (TiO2, Precheza a.s.). As a source of UV radiation was used UV LED diode Luminus, with peak wavelength at 365 nm. At the same time the effect of hydrogen peroxide (H2O2) or effect of pH was determined. Samples were preconcentrated by solid phase extraction (SPE) and analyzed by high performance liquid chromatography (HPLC). At the same time characteristics and capability of pharmaceutical removal from inlet of WWTP were discussed.

Název v anglickém jazyce

PHOTOCATALYTIC OXIDATION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Popis výsledku anglicky

Pharmaceuticals diclofenac and naproxen belong to class of non-steroidal anti-inflammatory drugs (NSAIDs). These substances are very often found in outlets of WWTP or in surface waters, because among all classes of pharmaceuticals, they are frequently prescribed and purchased. These substances have by their nature a strong biological effect, so non-target organisms are affected. For example diclofenac causes cytological malformations of liver tissue within a concentration 28 ?g/L (O. mykkis). Sensitive organisms to naproxen are crustaceans, where the EC50 for (C. dubia) is 330 ?g/L, but degradation products of this drug are significantly more toxic. EC50 for degradation products of naproxen to C. dubia are less than 100 ?g/L. Diclofenac and naproxen (500 ?g/L) were from model water samples removed by heterogeneous photocatalysis in 4L batch reactor. After irradiation of the catalyst, the system produces .OH radicals, which causes destruction of the organic substance. As the catalyst used was 0.5 g/L titanium dioxide (TiO2, Precheza a.s.). As a source of UV radiation was used UV LED diode Luminus, with peak wavelength at 365 nm. At the same time the effect of hydrogen peroxide (H2O2) or effect of pH was determined. Samples were preconcentrated by solid phase extraction (SPE) and analyzed by high performance liquid chromatography (HPLC). At the same time characteristics and capability of pharmaceutical removal from inlet of WWTP were discussed.

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 4th International Conference on Chemical Technology

ISBN

978-80-86238-94-4

ISSN

2336-811X

e-ISSN

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Počet stran výsledku

5

Strana od-do

440-444

Název nakladatele

Česká společnost průmyslové chemie

Místo vydání

Praha

Místo konání akce

Mikulov

Datum konání akce

25. 4. 2016

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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