Release kinetics of tramadol hydrochloride from solid drug formulations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39902243" target="_blank" >RIV/00216275:25310/16:39902243 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Release kinetics of tramadol hydrochloride from solid drug formulations

Popis výsledku v původním jazyce

The aim of this paper is to present the use of a reaction and a dissolution kinetic approach for evaluating the dissolution profile of a drug. As model substances, two controlled-release formulations (with different type of matrix) with tramadol hydrochloride were chosen. Release kinetics of tramadol hydrochloride was studied at isothermal conditions (37 oC) and at different pH values for media used for dissolution. The dissolution profiles obtained by using HPLC with UV detection were fitted by the first-order kinetic model, Korsmeyer-Peppas, Higuchi, and Weibull models. The main results of regression analysis were the determination of the first-order release rate constant (k1), the release exponent (n) from Korsmeyer-Peppas model, Higuchi constant (KH), and the parameters of Weibull model.

Název v anglickém jazyce

Release kinetics of tramadol hydrochloride from solid drug formulations

Popis výsledku anglicky

The aim of this paper is to present the use of a reaction and a dissolution kinetic approach for evaluating the dissolution profile of a drug. As model substances, two controlled-release formulations (with different type of matrix) with tramadol hydrochloride were chosen. Release kinetics of tramadol hydrochloride was studied at isothermal conditions (37 oC) and at different pH values for media used for dissolution. The dissolution profiles obtained by using HPLC with UV detection were fitted by the first-order kinetic model, Korsmeyer-Peppas, Higuchi, and Weibull models. The main results of regression analysis were the determination of the first-order release rate constant (k1), the release exponent (n) from Korsmeyer-Peppas model, Higuchi constant (KH), and the parameters of Weibull model.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology

ISSN

1211-5541

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

květen 2016

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

13

Strana od-do

67-79

Kód UT WoS článku

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EID výsledku v databázi Scopus

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