Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39902246" target="_blank" >RIV/00216275:25310/16:39902246 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/16:10328902

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ejps.2016.08.002" target="_blank" >http://dx.doi.org/10.1016/j.ejps.2016.08.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejps.2016.08.002" target="_blank" >10.1016/j.ejps.2016.08.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders

Popis výsledku v původním jazyce

The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses MethocelTM K4M Premium CR or MethocelTM K100M Premium CR were used as controlled release agents and Prosolv(R) SMCC 90 or DisintequikTM MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv(R) SMCC 90 and MethocelTM Premium CR cannot control the tramadol release effectively for > 12 h and tablets containing DisintequikTM MCC 25 and MethocelTM Premium CR > 8 h.

Název v anglickém jazyce

Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders

Popis výsledku anglicky

The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses MethocelTM K4M Premium CR or MethocelTM K100M Premium CR were used as controlled release agents and Prosolv(R) SMCC 90 or DisintequikTM MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv(R) SMCC 90 and MethocelTM Premium CR cannot control the tramadol release effectively for > 12 h and tablets containing DisintequikTM MCC 25 and MethocelTM Premium CR > 8 h.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pharmaceutical Sciences

ISSN

0928-0987

e-ISSN

—

Svazek periodika

95

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

36-45

Kód UT WoS článku

000390505100005

EID výsledku v databázi Scopus

2-s2.0-84997161412