A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10327961" target="_blank" >RIV/00216208:11160/16:10327961 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.degruyter.com/view/j/acph.2016.66.issue-3/acph-2016-0034/acph-2016-0034.xml" target="_blank" >http://www.degruyter.com/view/j/acph.2016.66.issue-3/acph-2016-0034/acph-2016-0034.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/acph-2016-0034" target="_blank" >10.1515/acph-2016-0034</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride
Popis výsledku v původním jazyce
The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv (R) SMCC 90 and Disintequik (TM) MCC 25. The selected types of hypromellose are Methocel (TM) Premium K4M and Methocel (TM) Premium K100M in 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets. The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv (R) SMCC 90 than in those containing Disintequik (TM) MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv (R) SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders.
Název v anglickém jazyce
A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride
Popis výsledku anglicky
The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv (R) SMCC 90 and Disintequik (TM) MCC 25. The selected types of hypromellose are Methocel (TM) Premium K4M and Methocel (TM) Premium K100M in 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets. The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv (R) SMCC 90 than in those containing Disintequik (TM) MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv (R) SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Pharmaceutica
ISSN
1330-0075
e-ISSN
—
Svazek periodika
66
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
CR - Kostarická republika
Počet stran výsledku
9
Strana od-do
433-441
Kód UT WoS článku
000379520700009
EID výsledku v databázi Scopus
2-s2.0-84978372406