Voltammetric Analysis of Disulfiram in Pharmaceuticals with a Cyclic Renewable Silver Amalgam Film Electrode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39911332" target="_blank" >RIV/00216275:25310/17:39911332 - isvavai.cz</a>

Výsledek na webu

<a href="http://journals.tubitak.gov.tr/chem/issues/kim-17-41-1/kim-41-1-10-1603-70.pdf" target="_blank" >http://journals.tubitak.gov.tr/chem/issues/kim-17-41-1/kim-41-1-10-1603-70.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3906/kim-1603-70" target="_blank" >10.3906/kim-1603-70</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetric Analysis of Disulfiram in Pharmaceuticals with a Cyclic Renewable Silver Amalgam Film Electrode

Popis výsledku v původním jazyce

Electrochemical properties of disulfiram, representative of highly significant bioactive compounds, were studied with a cyclic renewable silver amalgam film electrode (Hg(Ag)FE) using square wave cathodic stripping voltammetry (SWCSV). The influence of various factors such as pH, buffer concentration, buffer composition, and SWCSV parameters on current response was investigated. The optimum results in terms of signal shape and intensity were recorded in Britton Robinson buffer (pH 7.5) at 0.5 V versus Ag/AgCl/3 mol L-1 KCl. An elaborated electroanalytical procedure was used to determine disulfiram at the Hg(Ag)FE in the concentration range from 0.05 to 5.00 mu M. Precision, repeatability, and accuracy of the method as well as the influence of possible interferences were ascertained. The detection and quantification limits were 11 nM and 37 nM, respectively. The applicability of the developed method was tested in the determination of disulfiram in the commercial formulation Anticol. Thin-layer chromatography with image processing software was used to validate the accuracy of the method.

Název v anglickém jazyce

Voltammetric Analysis of Disulfiram in Pharmaceuticals with a Cyclic Renewable Silver Amalgam Film Electrode

Popis výsledku anglicky

Electrochemical properties of disulfiram, representative of highly significant bioactive compounds, were studied with a cyclic renewable silver amalgam film electrode (Hg(Ag)FE) using square wave cathodic stripping voltammetry (SWCSV). The influence of various factors such as pH, buffer concentration, buffer composition, and SWCSV parameters on current response was investigated. The optimum results in terms of signal shape and intensity were recorded in Britton Robinson buffer (pH 7.5) at 0.5 V versus Ag/AgCl/3 mol L-1 KCl. An elaborated electroanalytical procedure was used to determine disulfiram at the Hg(Ag)FE in the concentration range from 0.05 to 5.00 mu M. Precision, repeatability, and accuracy of the method as well as the influence of possible interferences were ascertained. The detection and quantification limits were 11 nM and 37 nM, respectively. The applicability of the developed method was tested in the determination of disulfiram in the commercial formulation Anticol. Thin-layer chromatography with image processing software was used to validate the accuracy of the method.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Turkish Journal of Chemistry

ISSN

1300-0527

e-ISSN

—

Svazek periodika

41

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

TR - Turecká republika

Počet stran výsledku

9

Strana od-do

116-124

Kód UT WoS článku

000395861400010

EID výsledku v databázi Scopus

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