Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39911283" target="_blank" >RIV/00216275:25310/18:39911283 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2174/0929867324666171121101245" target="_blank" >http://dx.doi.org/10.2174/0929867324666171121101245</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/0929867324666171121101245" target="_blank" >10.2174/0929867324666171121101245</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays

Popis výsledku v původním jazyce

Cancer is a widespread disease characterized by high mortality. To improve the survival rate or facilitate effective therapy, accurate and reliable diagnosis at an early stage is needed. For this reason, there is a continuous push to develop sensitive methods which can be used in cancer diagnosis. Current diagnosis relies on the quantification of cancer biomarkers defined as molecules that are measurable in body fluids or tissues and indicate a change in physiological processes with subsequent pathological manifestations. This contribution reviews recent developments in the area of electrochemical immunosensors applicable for the detection of cancer biomarkers that occur in a wide concentration range including extremely low levels, which are typical for the early stage of the disease. A summary of various antibody labels used for biomarker analysis and combined with electrochemical detection is presented. The potential of multiple biomarker analysis, with its indisputable clinical impact for accurate diagnosis, is also highlighted.

Název v anglickém jazyce

Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays

Popis výsledku anglicky

Cancer is a widespread disease characterized by high mortality. To improve the survival rate or facilitate effective therapy, accurate and reliable diagnosis at an early stage is needed. For this reason, there is a continuous push to develop sensitive methods which can be used in cancer diagnosis. Current diagnosis relies on the quantification of cancer biomarkers defined as molecules that are measurable in body fluids or tissues and indicate a change in physiological processes with subsequent pathological manifestations. This contribution reviews recent developments in the area of electrochemical immunosensors applicable for the detection of cancer biomarkers that occur in a wide concentration range including extremely low levels, which are typical for the early stage of the disease. A summary of various antibody labels used for biomarker analysis and combined with electrochemical detection is presented. The potential of multiple biomarker analysis, with its indisputable clinical impact for accurate diagnosis, is also highlighted.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10620 - Other biological topics

Projekt

<a href="/cs/project/GA15-16549S" target="_blank" >GA15-16549S: Vývoj ultrasensitivní imunomagnetické metody s kvantovými tečkami pro simultánní elektrochemickou detekci nádorových markerů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Medicinal Chemistry

ISSN

0929-8673

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

33

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

15

Strana od-do

3973-3987

Kód UT WoS článku

000448120700003

EID výsledku v databázi Scopus

2-s2.0-85055633444