Synthesis of 13,14-Dehydro-prostaglandins Synthetic Analogues: A Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39914612" target="_blank" >RIV/00216275:25310/19:39914612 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/19:10399697

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201902679" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201902679</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/slct.201902679" target="_blank" >10.1002/slct.201902679</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of 13,14-Dehydro-prostaglandins Synthetic Analogues: A Review

Popis výsledku v původním jazyce

Prostaglandins (PG) are a group of lipid mediators with several biological activities. Their structure includes a five-membered ring and two lateral chains (alpha and omega- chains). Due to their pharmaceutical and veterinary applications numerous synthetic analogues have been prepared and are described in literature. 13,14-dehydroPG are synthetic analogues including a triple bond in their skeleton which provide them a more preferable biological behaviour. However, these compounds require special approaches for their synthesis and attachment of its omega-chain when compared with allylic PG (double bond at position 13-14 of PG numbering). This review intends to summarize available strategies for the introduction of the omega-chains when a triple bond moiety (at position C13-14) is present.

Název v anglickém jazyce

Synthesis of 13,14-Dehydro-prostaglandins Synthetic Analogues: A Review

Popis výsledku anglicky

Prostaglandins (PG) are a group of lipid mediators with several biological activities. Their structure includes a five-membered ring and two lateral chains (alpha and omega- chains). Due to their pharmaceutical and veterinary applications numerous synthetic analogues have been prepared and are described in literature. 13,14-dehydroPG are synthetic analogues including a triple bond in their skeleton which provide them a more preferable biological behaviour. However, these compounds require special approaches for their synthesis and attachment of its omega-chain when compared with allylic PG (double bond at position 13-14 of PG numbering). This review intends to summarize available strategies for the introduction of the omega-chains when a triple bond moiety (at position C13-14) is present.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemistrySelect

ISSN

2365-6549

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

38

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

"11247–11255"

Kód UT WoS článku

000491201900006

EID výsledku v databázi Scopus

2-s2.0-85073537735