Method of UV-Metric and pH-Metric Determination of Dissociation Constants of Ionizable Drugs: Valsartan

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39914750" target="_blank" >RIV/00216275:25310/19:39914750 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007%2Fs10953-019-00913-y" target="_blank" >https://link.springer.com/article/10.1007%2Fs10953-019-00913-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10953-019-00913-y" target="_blank" >10.1007/s10953-019-00913-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Method of UV-Metric and pH-Metric Determination of Dissociation Constants of Ionizable Drugs: Valsartan

Popis výsledku v původním jazyce

Valsartan is used for treating high blood pressure, congestive heart failure and to increase the chances of living longer after a heart attack and to reduce the mortality rate for people with left ventricular dysfunction following a heart attack. Regression analysis of the pH-spectra with REACTLAB and of the pH-titration curve with ESAB determined two close consecutive dissociation constants. MARVIN and ACD/Percepta predicted two protonation sites. In water a soluble anion L2- forms two sparingly soluble species LH-, LH2. Although adjusted pH less affected the spectral changes in the chromophore, pK(a1)(T) = 3.70 +/- 0.12, pK(a2)(T) = 4.82 +/- 0.08 at 25 degrees C and pK(a1)(T) = 3.44 +/- 0.08, pK(a2)(T) = 4.67 +/- 0.02 at 37 degrees C in an aqueous phosphate buffer were determined. By regression analysis of potentiometric pH-titration curves and pK(a1)(T)= 3.51 +/- 0.01, pK(a2)(T) = 4.63 +/- 0.01, at 25 degrees C and pKT(a1) = 3.44 +/- 0.03, pK(a2)(T) = 4.51 +/- 0.03 at 37 degrees C in an aqueous medium were estimated. Positive enthalpy values Delta H-0(pK(a1)) = 10.33 kJ.mol(-1), Delta H-0(pK(a2)) = 17.70 kJ.mol(-1) showed that the dissociation process was endothermic. The standard state Gibbs energy changes are Delta G(0)(pK(a1)) = 20.03 kJ.mol(-1), Delta G(0)(pK(a2)) = 26.43 kJ.mol(-1) at 25 degrees C and the Delta S-0 at 25 degrees C and 37 degrees C are (Delta S-0(pK(a1)) = - 32.56 J.K-1.mol(-1), Delta S-0(pK(a2)) = - 29.26 J.K-1.mol(-1) at 25 degrees C and Delta S-0(pK(a1)) = - 30.01 J.K-1.mol(-1), Delta S-0(pK(a2)) = - 25.92 J.K-1.mol(-1) at 37 degrees C. [GRAPHICS] .

Název v anglickém jazyce

Method of UV-Metric and pH-Metric Determination of Dissociation Constants of Ionizable Drugs: Valsartan

Popis výsledku anglicky

Valsartan is used for treating high blood pressure, congestive heart failure and to increase the chances of living longer after a heart attack and to reduce the mortality rate for people with left ventricular dysfunction following a heart attack. Regression analysis of the pH-spectra with REACTLAB and of the pH-titration curve with ESAB determined two close consecutive dissociation constants. MARVIN and ACD/Percepta predicted two protonation sites. In water a soluble anion L2- forms two sparingly soluble species LH-, LH2. Although adjusted pH less affected the spectral changes in the chromophore, pK(a1)(T) = 3.70 +/- 0.12, pK(a2)(T) = 4.82 +/- 0.08 at 25 degrees C and pK(a1)(T) = 3.44 +/- 0.08, pK(a2)(T) = 4.67 +/- 0.02 at 37 degrees C in an aqueous phosphate buffer were determined. By regression analysis of potentiometric pH-titration curves and pK(a1)(T)= 3.51 +/- 0.01, pK(a2)(T) = 4.63 +/- 0.01, at 25 degrees C and pKT(a1) = 3.44 +/- 0.03, pK(a2)(T) = 4.51 +/- 0.03 at 37 degrees C in an aqueous medium were estimated. Positive enthalpy values Delta H-0(pK(a1)) = 10.33 kJ.mol(-1), Delta H-0(pK(a2)) = 17.70 kJ.mol(-1) showed that the dissociation process was endothermic. The standard state Gibbs energy changes are Delta G(0)(pK(a1)) = 20.03 kJ.mol(-1), Delta G(0)(pK(a2)) = 26.43 kJ.mol(-1) at 25 degrees C and the Delta S-0 at 25 degrees C and 37 degrees C are (Delta S-0(pK(a1)) = - 32.56 J.K-1.mol(-1), Delta S-0(pK(a2)) = - 29.26 J.K-1.mol(-1) at 25 degrees C and Delta S-0(pK(a1)) = - 30.01 J.K-1.mol(-1), Delta S-0(pK(a2)) = - 25.92 J.K-1.mol(-1) at 37 degrees C. [GRAPHICS] .

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Solution Chemistry

ISSN

0095-9782

e-ISSN

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Svazek periodika

48

Číslo periodika v rámci svazku

8-9

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

21

Strana od-do

1266-1286

Kód UT WoS článku

000489791300006

EID výsledku v databázi Scopus

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