A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39915240" target="_blank" >RIV/00216275:25310/19:39915240 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/19:10399482

Výsledek na webu

<a href="https://ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/28055" target="_blank" >https://ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/28055</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.32383/appdr/102487" target="_blank" >10.32383/appdr/102487</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets

Popis výsledku v původním jazyce

Avicel® HFE-102 is a co-processed dry binder containing 90% microcrystalline cellulose and 10% mannitol. This paper compares this co-processed dry binder and a physical mixture of related dry binders, microcrystalline cellulose (Avicel® PH-102) and mannitol (Pearlitol® 100SD) in the ratio of 9 : 1. Flow properties, compressibility, lubricant sensitivity, tensile strength, friability and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel® PH-102 alone. The flow properties of the co-processed dry binder Avicel® HFE-102 alone and the physical mixture were comparable. Avicel® HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity and tablet friability than the physical mixture of dry binders. Addition of lubricants exerted different effects on the disintegration of tablets. The co-processed excipient AvicelÆ HFE-102 is suitable for the use in orally dispersible tablets.

Název v anglickém jazyce

A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets

Popis výsledku anglicky

Avicel® HFE-102 is a co-processed dry binder containing 90% microcrystalline cellulose and 10% mannitol. This paper compares this co-processed dry binder and a physical mixture of related dry binders, microcrystalline cellulose (Avicel® PH-102) and mannitol (Pearlitol® 100SD) in the ratio of 9 : 1. Flow properties, compressibility, lubricant sensitivity, tensile strength, friability and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel® PH-102 alone. The flow properties of the co-processed dry binder Avicel® HFE-102 alone and the physical mixture were comparable. Avicel® HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity and tablet friability than the physical mixture of dry binders. Addition of lubricants exerted different effects on the disintegration of tablets. The co-processed excipient AvicelÆ HFE-102 is suitable for the use in orally dispersible tablets.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Poloniae Pharmaceutica - Drug Research

ISSN

0001-6837

e-ISSN

—

Svazek periodika

76

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

11

Strana od-do

355-365

Kód UT WoS článku

000468126500017

EID výsledku v databázi Scopus

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