A study of a novel coprocessed dry binder composed of alpha-lactose monohydrate, microcrystalline cellulose and corn starch
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10364556" target="_blank" >RIV/00216208:11160/17:10364556 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.tandfonline.com/doi/full/10.3109/10837450.2015.1131717" target="_blank" >http://www.tandfonline.com/doi/full/10.3109/10837450.2015.1131717</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2015.1131717" target="_blank" >10.3109/10837450.2015.1131717</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A study of a novel coprocessed dry binder composed of alpha-lactose monohydrate, microcrystalline cellulose and corn starch
Popis výsledku v původním jazyce
This paper deals with a study of the novel coprocessed dry binder Combilac(R), which contains 70% of alpha-lactose monohydrate, 20% of microcrystalline cellulose and 10% of native corn starch. These tests include flow properties, compressibility, lubricant sensitivity, tensile strength and disintegration time of tablets. Compressibility is evaluated by means of the energy profile of compression process, test of stress relaxation and tablet strength. The above-mentioned parameters are also evaluated in the physical mixture of alpha-lactose monohydrate, microcrystalline cellulose and native corn starch and compared with Combilac. Combilac shows much better flowability than the physical mixture of the used dry binders. Its compressibility is better, tablets possess a higher tensile strength. Neither Combilac, nor the physical mixture can be compressed without lubricants due to high friction and sticking to the matrix. Combilac has a higher lubricant sensitivity than the physical mixture of the dry binders. Disintegration time of Combilac tablets is comparable with the disintegration time of tablets made from the physical mixture.
Název v anglickém jazyce
A study of a novel coprocessed dry binder composed of alpha-lactose monohydrate, microcrystalline cellulose and corn starch
Popis výsledku anglicky
This paper deals with a study of the novel coprocessed dry binder Combilac(R), which contains 70% of alpha-lactose monohydrate, 20% of microcrystalline cellulose and 10% of native corn starch. These tests include flow properties, compressibility, lubricant sensitivity, tensile strength and disintegration time of tablets. Compressibility is evaluated by means of the energy profile of compression process, test of stress relaxation and tablet strength. The above-mentioned parameters are also evaluated in the physical mixture of alpha-lactose monohydrate, microcrystalline cellulose and native corn starch and compared with Combilac. Combilac shows much better flowability than the physical mixture of the used dry binders. Its compressibility is better, tablets possess a higher tensile strength. Neither Combilac, nor the physical mixture can be compressed without lubricants due to high friction and sticking to the matrix. Combilac has a higher lubricant sensitivity than the physical mixture of the dry binders. Disintegration time of Combilac tablets is comparable with the disintegration time of tablets made from the physical mixture.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Pharmaceutical Development and Technology
ISSN
1083-7450
e-ISSN
—
Svazek periodika
22
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
964-971
Kód UT WoS článku
000413910500004
EID výsledku v databázi Scopus
2-s2.0-84954201820