A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release of a Model Drug from Glyceryl Behenate Matrix Tablets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F21%3A39918263" target="_blank" >RIV/00216275:25310/21:39918263 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/21:10433670

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/ejlt.202000235" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ejlt.202000235</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ejlt.202000235" target="_blank" >10.1002/ejlt.202000235</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release of a Model Drug from Glyceryl Behenate Matrix Tablets

Popis výsledku v původním jazyce

This study is focused on the use of glyceryl behenate as a lipophilic excipient of matrix tablets providing controlled drug release. The aim of this study is to evaluate activation energy (EA) and changes of the thermodynamic parameters (Delta H, Delta S, Delta G) of a dissolution process. These values, which have not yet been published, can lead to better understanding of a drug release mechanism and can extend the use options of glyceryl behenate in the pharmaceutical industry. Values of Delta H, Delta S, Delta G and E-A, providing an overall thermodynamic view on the studied matrix tablets, are evaluated based on the temperature-dependences of the release rate constant of a model drug (temperature range 25 - 45 degrees C). The studied lipophilic matrix tablets contain 10% to 50% of glyceryl behenate. Dissolution testing is carried out in an aqueous solution of HCl with addition of NaCl (pH1.2). Positive values of Delta H in the range of 3.83 to 56.13 kJ mol(-1) and positive values of Delta G indicate that the dissolution of the studied glyceryl behenate matrix tablets is an endothermic process which does not proceed spontaneously (in a temperature range of 25 - 45 degrees C). The negative slope of the linear curves of enthalpy-entropy compensation confirms the entropy-driven dissolution.

Název v anglickém jazyce

A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release of a Model Drug from Glyceryl Behenate Matrix Tablets

Popis výsledku anglicky

This study is focused on the use of glyceryl behenate as a lipophilic excipient of matrix tablets providing controlled drug release. The aim of this study is to evaluate activation energy (EA) and changes of the thermodynamic parameters (Delta H, Delta S, Delta G) of a dissolution process. These values, which have not yet been published, can lead to better understanding of a drug release mechanism and can extend the use options of glyceryl behenate in the pharmaceutical industry. Values of Delta H, Delta S, Delta G and E-A, providing an overall thermodynamic view on the studied matrix tablets, are evaluated based on the temperature-dependences of the release rate constant of a model drug (temperature range 25 - 45 degrees C). The studied lipophilic matrix tablets contain 10% to 50% of glyceryl behenate. Dissolution testing is carried out in an aqueous solution of HCl with addition of NaCl (pH1.2). Positive values of Delta H in the range of 3.83 to 56.13 kJ mol(-1) and positive values of Delta G indicate that the dissolution of the studied glyceryl behenate matrix tablets is an endothermic process which does not proceed spontaneously (in a temperature range of 25 - 45 degrees C). The negative slope of the linear curves of enthalpy-entropy compensation confirms the entropy-driven dissolution.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Lipid Science and Technology

ISSN

1438-7697

e-ISSN

—

Svazek periodika

123

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

"2000235-1"-"2000235-8"

Kód UT WoS článku

000635804700001

EID výsledku v databázi Scopus

2-s2.0-85103427619