Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F09%3A00002097" target="_blank" >RIV/62157124:16370/09:00002097 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets

Popis výsledku v původním jazyce

The purpose of this experimental work was the development of hydrophilic - lipophilic matrix tablets for controlled release of slightly soluble drug represented here by diclofenac sodium. Drug dissolution profile optimization provided by soluble filler was studied. Matrix tablets were based on cetyl alcohol as the lipophilic carrier, povidone as the gel forming agent, and common soluble filler, i.e. lactose or sucrose of different particle size. Physical properties of tablets prepared by melt granulation and drug release in a phosphate buffer of pH 6.8 were evaluated. In vitro studies showed that used the filler type, filler to povidone ratio and sucrose particle size influenced the drug release rate. Diclofenac sodium dissolution profile could be changed within a wide range from about 50 % per 24 hours to almost 100 % in 10 hours. The release constant values confirmed that diclofenac sodium was released from matrices by the diffusion and anomalous transport. The influence of sucrose p

Název v anglickém jazyce

Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets

Popis výsledku anglicky

The purpose of this experimental work was the development of hydrophilic - lipophilic matrix tablets for controlled release of slightly soluble drug represented here by diclofenac sodium. Drug dissolution profile optimization provided by soluble filler was studied. Matrix tablets were based on cetyl alcohol as the lipophilic carrier, povidone as the gel forming agent, and common soluble filler, i.e. lactose or sucrose of different particle size. Physical properties of tablets prepared by melt granulation and drug release in a phosphate buffer of pH 6.8 were evaluated. In vitro studies showed that used the filler type, filler to povidone ratio and sucrose particle size influenced the drug release rate. Diclofenac sodium dissolution profile could be changed within a wide range from about 50 % per 24 hours to almost 100 % in 10 hours. The release constant values confirmed that diclofenac sodium was released from matrices by the diffusion and anomalous transport. The influence of sucrose p

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Drug Development and Industrial Pharmacy

ISSN

0363-9045

e-ISSN

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Svazek periodika

35

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

000268879400005

EID výsledku v databázi Scopus

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