The influence of process variables of preparation of oxycellulose beads on their dissolution profile

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872206" target="_blank" >RIV/62157124:16370/13:43872206 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The influence of process variables of preparation of oxycellulose beads on their dissolution profile

Popis výsledku v původním jazyce

Particles preparation from biodegradable polymers as carriers for the controlled release of drugs has been the focus of many investigations and the subject of a growing field of research in recent years. The aim of this study was to develop and optimizethe preparation of oxycellulose beads containing diclofenac sodium as a model drug. Particle size, surface, drug content and encapsulation efficiency were evaluated, drug dissolution profiles were measured and drug release mechanism estimated. The prepared oxycellulose beads were uniform in size with encapsulation efficiency ranging from 53.2 to 74.9%. The lower temperature of the crosslinking solution and its saturation with diclofenac sodium increased the encapsulation efficiency, especially when bothparameters were combined. The application of ultrasound had a negative effect on drug encapsulation. The dissolution of diclofenac sodium in pH 1.2 was close to zero as its solubility in this medium is very limited. The drug release in p

Název v anglickém jazyce

The influence of process variables of preparation of oxycellulose beads on their dissolution profile

Popis výsledku anglicky

Particles preparation from biodegradable polymers as carriers for the controlled release of drugs has been the focus of many investigations and the subject of a growing field of research in recent years. The aim of this study was to develop and optimizethe preparation of oxycellulose beads containing diclofenac sodium as a model drug. Particle size, surface, drug content and encapsulation efficiency were evaluated, drug dissolution profiles were measured and drug release mechanism estimated. The prepared oxycellulose beads were uniform in size with encapsulation efficiency ranging from 53.2 to 74.9%. The lower temperature of the crosslinking solution and its saturation with diclofenac sodium increased the encapsulation efficiency, especially when bothparameters were combined. The application of ultrasound had a negative effect on drug encapsulation. The dissolution of diclofenac sodium in pH 1.2 was close to zero as its solubility in this medium is very limited. The drug release in p

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Poloniae Pharmaceutica - Drug Research

ISSN

0001-6837

e-ISSN

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Svazek periodika

70

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

11

Strana od-do

271-281

Kód UT WoS článku

000316432100012

EID výsledku v databázi Scopus

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