Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870392" target="_blank" >RIV/62157124:16370/11:43870392 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1208/s12249-011-9696-9" target="_blank" >http://dx.doi.org/10.1208/s12249-011-9696-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1208/s12249-011-9696-9" target="_blank" >10.1208/s12249-011-9696-9</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility
Popis výsledku v původním jazyce
The aim of this study was to develop novel hydrogel-based beads and characterize their potential to deliver and release a drug exhibiting pH-dependent solubility into distal parts of gastrointestinal (GI) tract. Oxycellulose beads containing diclofenac sodium as a model drug were prepared by the ionotropic external gelation technique using calcium chloride solution as the crosslinking medium. Resulting beads were characterized in terms of particle shape and size, encapsulation efficacy, swelling abilityand in vitro drug release. Also, potential drug-polymer interactions were evaluated using Fourier transform infrared spectroscopy. The particle size was found to be 0.92-0.96 mm for inactive (oxycellulose only) and 1.47-1.60 mm for active (oxycellulose-diclofenac sodium) beads, respectively. In all cases, the sphericity factor was between 0.70 and 0.81 with higher values observed for samples containing higher polymer and drug concentrations. The swelling of inactive beads was found to b
Název v anglickém jazyce
Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility
Popis výsledku anglicky
The aim of this study was to develop novel hydrogel-based beads and characterize their potential to deliver and release a drug exhibiting pH-dependent solubility into distal parts of gastrointestinal (GI) tract. Oxycellulose beads containing diclofenac sodium as a model drug were prepared by the ionotropic external gelation technique using calcium chloride solution as the crosslinking medium. Resulting beads were characterized in terms of particle shape and size, encapsulation efficacy, swelling abilityand in vitro drug release. Also, potential drug-polymer interactions were evaluated using Fourier transform infrared spectroscopy. The particle size was found to be 0.92-0.96 mm for inactive (oxycellulose only) and 1.47-1.60 mm for active (oxycellulose-diclofenac sodium) beads, respectively. In all cases, the sphericity factor was between 0.70 and 0.81 with higher values observed for samples containing higher polymer and drug concentrations. The swelling of inactive beads was found to b
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/2A-1TP1%2F073" target="_blank" >2A-1TP1/073: *Nové farmaceutické produkty na bázi polysacharidů.</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
AAPS PHARMSCITECH
ISSN
1530-9932
e-ISSN
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Svazek periodika
12
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
1348-1357
Kód UT WoS článku
000297586500036
EID výsledku v databázi Scopus
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