Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility

Kód výsledku v IS VaVaI

RIV/62157124:16370/11:43870392 - isvavai.cz

Výsledek na webu

http://dx.doi.org/10.1208/s12249-011-9696-9

DOI - Digital Object Identifier

10.1208/s12249-011-9696-9

Jazyk výsledku

angličtina

Název v původním jazyce

Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility

Popis výsledku v původním jazyce

The aim of this study was to develop novel hydrogel-based beads and characterize their potential to deliver and release a drug exhibiting pH-dependent solubility into distal parts of gastrointestinal (GI) tract. Oxycellulose beads containing diclofenac sodium as a model drug were prepared by the ionotropic external gelation technique using calcium chloride solution as the crosslinking medium. Resulting beads were characterized in terms of particle shape and size, encapsulation efficacy, swelling abilityand in vitro drug release. Also, potential drug-polymer interactions were evaluated using Fourier transform infrared spectroscopy. The particle size was found to be 0.92-0.96 mm for inactive (oxycellulose only) and 1.47-1.60 mm for active (oxycellulose-diclofenac sodium) beads, respectively. In all cases, the sphericity factor was between 0.70 and 0.81 with higher values observed for samples containing higher polymer and drug concentrations. The swelling of inactive beads was found to b

Název v anglickém jazyce

Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility

Popis výsledku anglicky

The aim of this study was to develop novel hydrogel-based beads and characterize their potential to deliver and release a drug exhibiting pH-dependent solubility into distal parts of gastrointestinal (GI) tract. Oxycellulose beads containing diclofenac sodium as a model drug were prepared by the ionotropic external gelation technique using calcium chloride solution as the crosslinking medium. Resulting beads were characterized in terms of particle shape and size, encapsulation efficacy, swelling abilityand in vitro drug release. Also, potential drug-polymer interactions were evaluated using Fourier transform infrared spectroscopy. The particle size was found to be 0.92-0.96 mm for inactive (oxycellulose only) and 1.47-1.60 mm for active (oxycellulose-diclofenac sodium) beads, respectively. In all cases, the sphericity factor was between 0.70 and 0.81 with higher values observed for samples containing higher polymer and drug concentrations. The swelling of inactive beads was found to b

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

2A-1TP1/073: *Nové farmaceutické produkty na bázi polysacharidů.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
S - Specificky vyzkum na vysokych skolach
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

AAPS PHARMSCITECH

ISSN

1530-9932

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

1348-1357

Kód UT WoS článku

000297586500036

EID výsledku v databázi Scopus

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