Enhancement of biocompatibility of anodic nanotube structures on biomedical Ti–6Al–4V alloy via ultrathin TiO2 coatings

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F24%3A39921853" target="_blank" >RIV/00216275:25310/24:39921853 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1515810/full" target="_blank" >https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1515810/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fbioe.2024.1515810" target="_blank" >10.3389/fbioe.2024.1515810</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enhancement of biocompatibility of anodic nanotube structures on biomedical Ti–6Al–4V alloy via ultrathin TiO2 coatings

Popis výsledku v původním jazyce

This work aims to describe the effect of the surface modification of TiO2nanotube (TNT) layers on Ti-6Al-4V (TiAlV) alloy by ultrathin TiO2 coatingsprepared via Atomic Layer Deposition (ALD) on the growth of MG-63osteoblastic cells. The TNT layers with two distinctly different inner diameters,namely ~15 nm and ~50 nm, were prepared via anodic oxidation of the TiAlV alloy.Flat, i.e., non-anodized, TiAlV alloy foils were used as reference substrates.Additionally, a part of the TNT layers and alloy foils was coated with ultrathincoatings of TiO2 by ALD. The number of TiO2 ALD cycles used was 1 and 5 leadingto a nominal TiO2 thickness of ~0.055 and ~0.3 nm, respectively. The ultrathinTiO2 coating by ALD enabled to optimize the surface hydrophilicity for optimalcell growth. In addition, coatings shaded impurities of V- and F-based species(stemming from the alloy and the anodization electrolyte) that affect thebiocompatibility of the tested materials while preserving the original structureand morphology. The evaluation of the biocompatibility before and after TiO2ALD coating on TiAlV flat surfaces and TNT layers was carried out using MG-63osteoblastic cells and compared after incubation for up to 96 h. The cell growth,adhesion, and proliferation of the MG-63 on TiAlV foils and TNT layers showedsignificant enhancement after the surface modification by TiO2 ALD.

Název v anglickém jazyce

Enhancement of biocompatibility of anodic nanotube structures on biomedical Ti–6Al–4V alloy via ultrathin TiO2 coatings

Popis výsledku anglicky

This work aims to describe the effect of the surface modification of TiO2nanotube (TNT) layers on Ti-6Al-4V (TiAlV) alloy by ultrathin TiO2 coatingsprepared via Atomic Layer Deposition (ALD) on the growth of MG-63osteoblastic cells. The TNT layers with two distinctly different inner diameters,namely ~15 nm and ~50 nm, were prepared via anodic oxidation of the TiAlV alloy.Flat, i.e., non-anodized, TiAlV alloy foils were used as reference substrates.Additionally, a part of the TNT layers and alloy foils was coated with ultrathincoatings of TiO2 by ALD. The number of TiO2 ALD cycles used was 1 and 5 leadingto a nominal TiO2 thickness of ~0.055 and ~0.3 nm, respectively. The ultrathinTiO2 coating by ALD enabled to optimize the surface hydrophilicity for optimalcell growth. In addition, coatings shaded impurities of V- and F-based species(stemming from the alloy and the anodization electrolyte) that affect thebiocompatibility of the tested materials while preserving the original structureand morphology. The evaluation of the biocompatibility before and after TiO2ALD coating on TiAlV flat surfaces and TNT layers was carried out using MG-63osteoblastic cells and compared after incubation for up to 96 h. The cell growth,adhesion, and proliferation of the MG-63 on TiAlV foils and TNT layers showedsignificant enhancement after the surface modification by TiO2 ALD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20506 - Coating and films

Projekt

<a href="/cs/project/EF17_048%2F0007421" target="_blank" >EF17_048/0007421: Posilování mezioborové spolupráce ve výzkumu nanomateriálů a při studiu jejich účinků na živé organismy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Bioengineering and Biotechnology

ISSN

2296-4185

e-ISSN

2296-4185

Svazek periodika

12

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

1515810

Kód UT WoS článku

001378695000001

EID výsledku v databázi Scopus

2-s2.0-85212076032