Recent advances, challenges, and future directions in the mass spectrometry analysis of glycosphingolipids in biological samples
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F24%3A39921963" target="_blank" >RIV/00216275:25310/24:39921963 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60076658:12310/24:43908817
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0165993624003108?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165993624003108?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trac.2024.117827" target="_blank" >10.1016/j.trac.2024.117827</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Recent advances, challenges, and future directions in the mass spectrometry analysis of glycosphingolipids in biological samples
Popis výsledku v původním jazyce
Mass spectrometry combined with (ultra)high-performance liquid chromatography has proved to be the most suitable method for the analysis of glycosphingolipids (GSLs). An increasing number of studies have focused on the analysis of not only simple but also complex GSLs with the aim of clarifying their biochemical functions in animals and humans. Despite the tremendous improvements in sample preparation and analytical methods in glycosphingolipidomics, there are still several major issues that complicate the comprehensive analysis of GSLs. This review aims to provide the latest advances, developments, and instrumental innovations in the analysis of GSLs in biological samples. The current barriers and challenges facing the qualitative and quantitative analysis of GSLs are highlighted and critically assessed. Overcoming these bottlenecks is crucial for high-throughput GSLs profiling, which is essential to reveal their clinical potential and to understand their role in the pathophysiology of serious diseases, such as cancer.
Název v anglickém jazyce
Recent advances, challenges, and future directions in the mass spectrometry analysis of glycosphingolipids in biological samples
Popis výsledku anglicky
Mass spectrometry combined with (ultra)high-performance liquid chromatography has proved to be the most suitable method for the analysis of glycosphingolipids (GSLs). An increasing number of studies have focused on the analysis of not only simple but also complex GSLs with the aim of clarifying their biochemical functions in animals and humans. Despite the tremendous improvements in sample preparation and analytical methods in glycosphingolipidomics, there are still several major issues that complicate the comprehensive analysis of GSLs. This review aims to provide the latest advances, developments, and instrumental innovations in the analysis of GSLs in biological samples. The current barriers and challenges facing the qualitative and quantitative analysis of GSLs are highlighted and critically assessed. Overcoming these bottlenecks is crucial for high-throughput GSLs profiling, which is essential to reveal their clinical potential and to understand their role in the pathophysiology of serious diseases, such as cancer.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10400 - Chemical sciences
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
TrAC - Trends in Analytical Chemistry
ISSN
0165-9936
e-ISSN
1879-3142
Svazek periodika
178
Číslo periodika v rámci svazku
September 2024
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
11
Strana od-do
117827
Kód UT WoS článku
001260563400001
EID výsledku v databázi Scopus
2-s2.0-85196723135