Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25520%2F17%3A39912129" target="_blank" >RIV/00216275:25520/17:39912129 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/17:10367923 RIV/00179906:_____/17:10367923 RIV/61989592:15110/17:73583817

Výsledek na webu

<a href="http://dx.doi.org/10.1515/pterid-2017-0018" target="_blank" >http://dx.doi.org/10.1515/pterid-2017-0018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/pterid-2017-0018" target="_blank" >10.1515/pterid-2017-0018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study

Popis výsledku v původním jazyce

The aim of the present pilot study was to investigate the concentrations of neopterin, kynurenine and tryptophan in wound secretion in patients undergoing surgery for breast cancer or malignant melanoma. Twenty-two patients, 16 females and 6 males, undergoing surgery for breast cancer (n = 15) or malignant melanoma (n = 7) were evaluated. Neopterin, kynurenine and tryptophan were determined using a high-performance liquid chromatography method. When the concentrations in wound secretions from the primary breast tumor and the axilla were compared, the neopterin/tryptophan ratio was significantly higher in the tumor wound secretions (0.92 +/- 0.41 vs. 0.61 +/- 0.14 mmol/mol; p = 0.049), but no significant differences were observed in neopterin (49.2 +/- 28.6 vs. 31.5 +/- 11.1 nmol/L), tryptophan (52.9 +/- 13.0 vs. 51.2 +/- 13.3 mu mol/L) and kynurenine concentrations 5.97 +/- 7.49 vs. 5.34 +/- 6.25 mu mol/L) and kynurenine/tryptophan ratio (108.1 +/- 107.7 vs. 103.5 +/- 106.7 mmol/mol). No marked differences were noted in neopterin, tryptophan and kynurenine concentrations and kynurenine/tryptophan and neopterin/tryptophan ratios in sequential samples from the axilla of breast cancer patients obtained on days 1 and 2. In conclusion, present data demonstrate that the measurement of neopterin, kynurenine and tryptophan can be used to monitor local immune response after cancer surgery.

Název v anglickém jazyce

Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study

Popis výsledku anglicky

The aim of the present pilot study was to investigate the concentrations of neopterin, kynurenine and tryptophan in wound secretion in patients undergoing surgery for breast cancer or malignant melanoma. Twenty-two patients, 16 females and 6 males, undergoing surgery for breast cancer (n = 15) or malignant melanoma (n = 7) were evaluated. Neopterin, kynurenine and tryptophan were determined using a high-performance liquid chromatography method. When the concentrations in wound secretions from the primary breast tumor and the axilla were compared, the neopterin/tryptophan ratio was significantly higher in the tumor wound secretions (0.92 +/- 0.41 vs. 0.61 +/- 0.14 mmol/mol; p = 0.049), but no significant differences were observed in neopterin (49.2 +/- 28.6 vs. 31.5 +/- 11.1 nmol/L), tryptophan (52.9 +/- 13.0 vs. 51.2 +/- 13.3 mu mol/L) and kynurenine concentrations 5.97 +/- 7.49 vs. 5.34 +/- 6.25 mu mol/L) and kynurenine/tryptophan ratio (108.1 +/- 107.7 vs. 103.5 +/- 106.7 mmol/mol). No marked differences were noted in neopterin, tryptophan and kynurenine concentrations and kynurenine/tryptophan and neopterin/tryptophan ratios in sequential samples from the axilla of breast cancer patients obtained on days 1 and 2. In conclusion, present data demonstrate that the measurement of neopterin, kynurenine and tryptophan can be used to monitor local immune response after cancer surgery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

<a href="/cs/project/NV16-32030A" target="_blank" >NV16-32030A: Využití disulfiramu v nové roli léčebného prostředku pro rekurentní metastatické nádory prsu rezistentní na chemo a endokrinní terapii</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pteridines

ISSN

0933-4807

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

205-211

Kód UT WoS článku

000416827700011

EID výsledku v databázi Scopus

2-s2.0-85037864177