Study of Droplet Transport and Deposition in Human Airways under Realistic Conditions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F09%3APU83591" target="_blank" >RIV/00216305:26210/09:PU83591 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of Droplet Transport and Deposition in Human Airways under Realistic Conditions

Popis výsledku v původním jazyce

Transport of aerosol particles in respiratory tract attracts more and more attention in view of tar-geted delivery of therapeutic sprays to treat wide spectrum of not only pulmonary diseases. To enable optical measurement of aerosol transport with air asworking fluid, we created realistic thin-walled transparent airway model. The non-symmetric bifurcation model reflects real non-planar lung geometry and spans from throat to 3rd-4th generation of bronchi. A pneumatic mecha-nism generated oscillating airflow into the model. Monodisperse droplets were mixed with air at the model entry. Velocity and size measurement of the particles were done using Phase/Doppler Particle Analyzer (P/DPA). Difference between air supply from the "mouth side" and the "alveoli side" into simple bifurcation lung model was investigated. We observed increased turbulence intensity especially during expira-tion phase in case of the mouth side control compared to alveoli side control. The reason of this distinctio

Název v anglickém jazyce

Study of Droplet Transport and Deposition in Human Airways under Realistic Conditions

Popis výsledku anglicky

Transport of aerosol particles in respiratory tract attracts more and more attention in view of tar-geted delivery of therapeutic sprays to treat wide spectrum of not only pulmonary diseases. To enable optical measurement of aerosol transport with air asworking fluid, we created realistic thin-walled transparent airway model. The non-symmetric bifurcation model reflects real non-planar lung geometry and spans from throat to 3rd-4th generation of bronchi. A pneumatic mecha-nism generated oscillating airflow into the model. Monodisperse droplets were mixed with air at the model entry. Velocity and size measurement of the particles were done using Phase/Doppler Particle Analyzer (P/DPA). Difference between air supply from the "mouth side" and the "alveoli side" into simple bifurcation lung model was investigated. We observed increased turbulence intensity especially during expira-tion phase in case of the mouth side control compared to alveoli side control. The reason of this distinctio

Druh

O - Ostatní výsledky

CEP obor

BK - Mechanika tekutin

OECD FORD obor

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Projekt

<a href="/cs/project/GA101%2F07%2F0862" target="_blank" >GA101/07/0862: Experimentální studie dynamiky proudění, transportu a depozice aerosolů v postupně se větvících minikanálech</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů