Structure-based constitutive model can accurately predicts planar biaxial properties of arotic wall tissue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F15%3APU113149" target="_blank" >RIV/00216305:26210/15:PU113149 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.actbio.2014.11.043" target="_blank" >http://dx.doi.org/10.1016/j.actbio.2014.11.043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.actbio.2014.11.043" target="_blank" >10.1016/j.actbio.2014.11.043</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Structure-based constitutive model can accurately predicts planar biaxial properties of arotic wall tissue

Popis výsledku v původním jazyce

Introduction. Structure-based constitutive models might help exploring mechanisms by which arterial wall histology is linked to wall mechanics. This study aims at validating a recently proposed structure-based constitutive model. Specifically, the models ability to predict mechanical biaxial response of porcine aortic tissue with predefined collagen structure was tested. Materials and Methods. Histological slices from porcine thoracic aorta wall (n=9) were automatically processed to quantify the collagen fiber organization, and mechanical testing identified non-linear properties of the wall samples (n=18) over a wide range of biaxial stretches. Histological and mechanical experimental data was used to identify model parameters of a multi-scale constitutive description for arterial layers proposed recently. The model predictive capability was tested with respect to interpolation and extrapolation. Results. Collagen in the media was predominantly aligned in circumferential direction (planar von Mises distribution with concentration parameter b_M=1.03±0.23), and its coherence decreased gradually from the luminal to the abluminal tissue layers (inner media: b=1.54±0.40; outer media: b=0.72±0.20). In contrast, the collagen in the adventitia was aligned almost isotropically (b_A=0.27±0.11), and no features like families of coherent fibers were identified. The applied constitutive model captured the aorta biaxial properties accurately (coefficient of determination R^2=0.95±0.03) over the entire range of biaxial deformations and with physically meaningful model parameters. Good predictive properties, well outside the parameter identification space, were observed (R^2=0.92±0.04). Conclusions. Multi-scale constitutive models equipped with realistic micro-histological data can predict macroscopic non-linear aorta wall properties. Collagen largely defines already low strain properties of media, which explains the origin of wall anisotropy seen at this strain level. Structure

Název v anglickém jazyce

Structure-based constitutive model can accurately predicts planar biaxial properties of arotic wall tissue

Popis výsledku anglicky

Introduction. Structure-based constitutive models might help exploring mechanisms by which arterial wall histology is linked to wall mechanics. This study aims at validating a recently proposed structure-based constitutive model. Specifically, the models ability to predict mechanical biaxial response of porcine aortic tissue with predefined collagen structure was tested. Materials and Methods. Histological slices from porcine thoracic aorta wall (n=9) were automatically processed to quantify the collagen fiber organization, and mechanical testing identified non-linear properties of the wall samples (n=18) over a wide range of biaxial stretches. Histological and mechanical experimental data was used to identify model parameters of a multi-scale constitutive description for arterial layers proposed recently. The model predictive capability was tested with respect to interpolation and extrapolation. Results. Collagen in the media was predominantly aligned in circumferential direction (planar von Mises distribution with concentration parameter b_M=1.03±0.23), and its coherence decreased gradually from the luminal to the abluminal tissue layers (inner media: b=1.54±0.40; outer media: b=0.72±0.20). In contrast, the collagen in the adventitia was aligned almost isotropically (b_A=0.27±0.11), and no features like families of coherent fibers were identified. The applied constitutive model captured the aorta biaxial properties accurately (coefficient of determination R^2=0.95±0.03) over the entire range of biaxial deformations and with physically meaningful model parameters. Good predictive properties, well outside the parameter identification space, were observed (R^2=0.92±0.04). Conclusions. Multi-scale constitutive models equipped with realistic micro-histological data can predict macroscopic non-linear aorta wall properties. Collagen largely defines already low strain properties of media, which explains the origin of wall anisotropy seen at this strain level. Structure

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Biomaterialia

ISSN

1742-7061

e-ISSN

1878-7568

Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

133-145

Kód UT WoS článku

000349733800014

EID výsledku v databázi Scopus

2-s2.0-84921839868