Effect of Hyaluronic Acid Molecular Weight on Friction of Articular Cartilage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F19%3APU132261" target="_blank" >RIV/00216305:26210/19:PU132261 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Hyaluronic Acid Molecular Weight on Friction of Articular Cartilage

Popis výsledku v původním jazyce

Hyaluronic acid (HA) is among others one of the component of synovial fluid (SF) and is the main component which affects the rheology of SF. However, during various degenerative joint diseases like osteoarthritis, the concentration and molecular weight of HA in SF is decreasing. In recent times, injections with exogenous HA are gaining popularity as a one of the methods for non-invasive treatment of osteoarthritis. Exogenous HA should improve rheological properties of osteoarthritic SF and has also many physiological effects. One of the key parameters which affects the rheology of HA and the efficiency of viscosupplementation is the molecular weight of HA. In this study, the changes in coefficient of friction between intact porcine cartilage and glass plate during reciprocating sliding tests were analyzed to understand how the changes in molecular weight of HA affects the friction of articular cartilage model. The changes in friction between osteoarthritic SF and mixtures of SF and HA with different molecular weight were also analyzed to assess the significance of exogenous HA molecular weight on cartilage friction after viscosupplementation.

Název v anglickém jazyce

Effect of Hyaluronic Acid Molecular Weight on Friction of Articular Cartilage

Popis výsledku anglicky

Hyaluronic acid (HA) is among others one of the component of synovial fluid (SF) and is the main component which affects the rheology of SF. However, during various degenerative joint diseases like osteoarthritis, the concentration and molecular weight of HA in SF is decreasing. In recent times, injections with exogenous HA are gaining popularity as a one of the methods for non-invasive treatment of osteoarthritis. Exogenous HA should improve rheological properties of osteoarthritic SF and has also many physiological effects. One of the key parameters which affects the rheology of HA and the efficiency of viscosupplementation is the molecular weight of HA. In this study, the changes in coefficient of friction between intact porcine cartilage and glass plate during reciprocating sliding tests were analyzed to understand how the changes in molecular weight of HA affects the friction of articular cartilage model. The changes in friction between osteoarthritic SF and mixtures of SF and HA with different molecular weight were also analyzed to assess the significance of exogenous HA molecular weight on cartilage friction after viscosupplementation.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20301 - Mechanical engineering

Projekt

<a href="/cs/project/LTAUSA17150" target="_blank" >LTAUSA17150: Vliv tribologických procesů na životnost náhrad kolenního kloubu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings on Engineering Sciences - 16th International Conference on Tribology

ISBN

—

ISSN

2620-2832

e-ISSN

—

Počet stran výsledku

5

Strana od-do

693-697

Název nakladatele

University of Kragujevac, Faculty of Engineering

Místo vydání

Kragujevac

Místo konání akce

Kragujevac

Datum konání akce

15. 5. 2019

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—