A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU144857" target="_blank" >RIV/00216305:26210/22:PU144857 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/22:10445166

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.b.35114" target="_blank" >10.1002/jbm.b.35114</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase

Popis výsledku v původním jazyce

Osteoarthritis (OA) is one of the most common musculoskeletal disorders in the world. OA is often associated with the loss of viscoelastic and tribological properties of synovial fluid (SF) due to degradation of hyaluronic acid (HA) by reactive oxygen species (ROS) and hyaluronidases. Viscosupplementation is one of the ways how to effectively restore SF functions. However, current viscosupplementation products provide only temporal therapeutic effect because of short biological half-life. In this article we describe a novel device for viscosupplementation (NV) based on the cross-linked tyramine derivative of HA, chondroitin sulfate (CS), and high molecular weight HA by online determination of viscoelastic properties loss during degradation by ROS and hyaluronidase. Rheological and tribological properties of developed viscosupplement were compared with HA solutions with different molecular weights in the range 500–2000 kDa, which are currently commonly used as medical devices for viscosupplementation treatment. Moreover, based on clinical practice and scientific literature all samples were also diluted by model OA SF in the ratio 1:1 (vol/vol) to better predict final properties after injection to the joint. The observed results confirmed that NV exhibits appropriate rheological properties (viscosity, elastic, and viscous moduli) comparable with healthy SF and maintain them during degradation for a significantly longer time than HA solutions with molecular weight in the range 500–2000 kDa and cross-linked material without CS.

Název v anglickém jazyce

A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase

Popis výsledku anglicky

Osteoarthritis (OA) is one of the most common musculoskeletal disorders in the world. OA is often associated with the loss of viscoelastic and tribological properties of synovial fluid (SF) due to degradation of hyaluronic acid (HA) by reactive oxygen species (ROS) and hyaluronidases. Viscosupplementation is one of the ways how to effectively restore SF functions. However, current viscosupplementation products provide only temporal therapeutic effect because of short biological half-life. In this article we describe a novel device for viscosupplementation (NV) based on the cross-linked tyramine derivative of HA, chondroitin sulfate (CS), and high molecular weight HA by online determination of viscoelastic properties loss during degradation by ROS and hyaluronidase. Rheological and tribological properties of developed viscosupplement were compared with HA solutions with different molecular weights in the range 500–2000 kDa, which are currently commonly used as medical devices for viscosupplementation treatment. Moreover, based on clinical practice and scientific literature all samples were also diluted by model OA SF in the ratio 1:1 (vol/vol) to better predict final properties after injection to the joint. The observed results confirmed that NV exhibits appropriate rheological properties (viscosity, elastic, and viscous moduli) comparable with healthy SF and maintain them during degradation for a significantly longer time than HA solutions with molecular weight in the range 500–2000 kDa and cross-linked material without CS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20301 - Mechanical engineering

Projekt

<a href="/cs/project/GA20-00483S" target="_blank" >GA20-00483S: Vliv viskosuplementace kloubní kapaliny na tření a mazání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)

ISSN

1552-4973

e-ISSN

1552-4981

Svazek periodika

110

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

17

Strana od-do

2595-2611

Kód UT WoS článku

000813662300001

EID výsledku v databázi Scopus

2-s2.0-85132142549