Microstructure of Selective Laser Melted Titanium Lattices and In Vitro Cell Behaviour

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F21%3APU142437" target="_blank" >RIV/00216305:26210/21:PU142437 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.confer.cz/metal/2021/4259-microstructure-of-selective-laser-melted-titanium-lattices-and-in-vitro-cell-behaviour" target="_blank" >https://www.confer.cz/metal/2021/4259-microstructure-of-selective-laser-melted-titanium-lattices-and-in-vitro-cell-behaviour</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/metal.2021.4259" target="_blank" >10.37904/metal.2021.4259</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microstructure of Selective Laser Melted Titanium Lattices and In Vitro Cell Behaviour

Popis výsledku v původním jazyce

Selective laser melting (SLM) is a metal additive manufacturing technology that allows the fabrication of complex near-net-shape titanium parts. Among possible applications, titanium is important for the biomedical sector, in particular for orthopaedics due to its low elastic modulus, biocompatibility, high mechanical strength and corrosion resistance. Several studies show the structural properties and mechanical behaviour of titanium lattices that in parallel exhibited the porosity, mechanical strength and elastic modulus of trabecular bone. However, less attention has been devoted to study the biological response to titanium parts fabricated by SLM. Therefore, this work aimed to fabricate commercially pure titanium lattices by SLM and study the behaviour of bone-forming cells cultured on the lattices. The results show that Saos-2 osteoblast-like cells proliferated and covered the entire available surface of the titanium lattices becoming confluent and quiescent. The activity of alkaline phosphatase and the production of extracellular calcium deposits confirmed the growth of viable and mature osteoblasts. The cytocompatibility of the titanium lattices is an additional advantage that adds to the possibility to mimic the porosity and mechanical properties of bone by computer-aided design and subsequently implement the lattice fabrication by SLM, fitting the requirements of individual patients and, consequently, offering a broad range of new bone repair alternatives in orthopaedics. Keywords: selective laser melting, titanium, microstructure, osteoblast, cytocompatibility.

Název v anglickém jazyce

Microstructure of Selective Laser Melted Titanium Lattices and In Vitro Cell Behaviour

Popis výsledku anglicky

Selective laser melting (SLM) is a metal additive manufacturing technology that allows the fabrication of complex near-net-shape titanium parts. Among possible applications, titanium is important for the biomedical sector, in particular for orthopaedics due to its low elastic modulus, biocompatibility, high mechanical strength and corrosion resistance. Several studies show the structural properties and mechanical behaviour of titanium lattices that in parallel exhibited the porosity, mechanical strength and elastic modulus of trabecular bone. However, less attention has been devoted to study the biological response to titanium parts fabricated by SLM. Therefore, this work aimed to fabricate commercially pure titanium lattices by SLM and study the behaviour of bone-forming cells cultured on the lattices. The results show that Saos-2 osteoblast-like cells proliferated and covered the entire available surface of the titanium lattices becoming confluent and quiescent. The activity of alkaline phosphatase and the production of extracellular calcium deposits confirmed the growth of viable and mature osteoblasts. The cytocompatibility of the titanium lattices is an additional advantage that adds to the possibility to mimic the porosity and mechanical properties of bone by computer-aided design and subsequently implement the lattice fabrication by SLM, fitting the requirements of individual patients and, consequently, offering a broad range of new bone repair alternatives in orthopaedics. Keywords: selective laser melting, titanium, microstructure, osteoblast, cytocompatibility.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

<a href="/cs/project/GA19-22662S" target="_blank" >GA19-22662S: In situ precipitace hydroxyapatitu uvnitř hierarchických titanových struktur: nový koncept pro dosažení kompozitů bez nežádoucích fází</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings 30th Anniversary International Conference on Metallurgy and Materials

ISBN

978-80-87294-99-4

ISSN

—

e-ISSN

—

Počet stran výsledku

6

Strana od-do

1179-1185

Název nakladatele

Tanger

Místo vydání

neuveden

Místo konání akce

Brno

Datum konání akce

26. 5. 2021

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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