Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU146717" target="_blank" >RIV/00216305:26210/22:PU146717 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer
Popis výsledku v původním jazyce
Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.
Název v anglickém jazyce
Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer
Popis výsledku anglicky
Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
20303 - Thermodynamics
Návaznosti výsledku
Projekt
<a href="/cs/project/GA22-20357S" target="_blank" >GA22-20357S: Měření a počítačová simulace transportu vláknitých aerosolů v proudění s vysokými gradienty rychlosti a interakce vláken se stěnou</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů