Influence of nebulizer pressure drop on breathing profiles and aerosol deposition in human airways

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F26%3A0199208" target="_blank" >RIV/00216305:26210/26:0199208 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0021850225000977" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0021850225000977</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jaerosci.2025.106620" target="_blank" >10.1016/j.jaerosci.2025.106620</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of nebulizer pressure drop on breathing profiles and aerosol deposition in human airways

Popis výsledku v původním jazyce

Breathing flow rate profiles are crucial for predicting aerosol drug delivery. While aerosol particle characteristics are determined by the inhalation device, breathing profiles are patient-specific, making them an essential topic for personalized medicine. This study investigates the influence of nebulizer pressure drop on breathing profiles and subsequent aerosol deposition within human airways. Ten male subjects performed spontaneous, and slow and deep breathing manoeuvres through three different nebulizers (one jet and two mesh nebulizers). Breathing profiles were recorded, and the impact of nebulizer pressure drop on flow rate profiles was analyzed. Computational modelling of airway aerosol deposition was performed for particles ranging from 1 to 10 mu m in diameter, based on the recorded boundary conditions. The jet nebulizer exhibited the most significant flow rate decrease due to its high pressure drop, increasing particle deposition in the lower airways. These findings are important for personalized modelling and the application of a digital twin approach in treatment design, leading to more effective and targeted drug delivery.

Název v anglickém jazyce

Influence of nebulizer pressure drop on breathing profiles and aerosol deposition in human airways

Popis výsledku anglicky

Breathing flow rate profiles are crucial for predicting aerosol drug delivery. While aerosol particle characteristics are determined by the inhalation device, breathing profiles are patient-specific, making them an essential topic for personalized medicine. This study investigates the influence of nebulizer pressure drop on breathing profiles and subsequent aerosol deposition within human airways. Ten male subjects performed spontaneous, and slow and deep breathing manoeuvres through three different nebulizers (one jet and two mesh nebulizers). Breathing profiles were recorded, and the impact of nebulizer pressure drop on flow rate profiles was analyzed. Computational modelling of airway aerosol deposition was performed for particles ranging from 1 to 10 mu m in diameter, based on the recorded boundary conditions. The jet nebulizer exhibited the most significant flow rate decrease due to its high pressure drop, increasing particle deposition in the lower airways. These findings are important for personalized modelling and the application of a digital twin approach in treatment design, leading to more effective and targeted drug delivery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20303 - Thermodynamics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF AEROSOL SCIENCE

ISSN

0021-8502

e-ISSN

1879-1964

Svazek periodika

188

Číslo periodika v rámci svazku

August 2025

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

18

Strana od-do

—

Kód UT WoS článku

001504384200001

EID výsledku v databázi Scopus

2-s2.0-105007035742