Toward Cartilage-Mimicking Biomaterials: Biotribological, Biochemical and Structural Evaluation of pHEMA and PVA-Based Hydrogels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F26%3A0200519" target="_blank" >RIV/00216305:26210/26:0200519 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/25:63597358

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsomega.5c10283" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.5c10283</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsomega.5c10283" target="_blank" >10.1021/acsomega.5c10283</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Toward Cartilage-Mimicking Biomaterials: Biotribological, Biochemical and Structural Evaluation of pHEMA and PVA-Based Hydrogels

Popis výsledku v původním jazyce

This study compares the biotribological and structural behavior of PVA and pHEMA hydrogels under conditions simulating the cartilage environment to understand the lubrication mechanisms. PVA samples exhibited very low apparent friction coefficients and high-water uptake due to their hydrophilic, hydroxyl-rich network. In contrast, pHEMA hydrogels showed higher friction but substantially enhanced wear resistance, particularly under extended sliding against rough counterfaces. While PVA offers excellent lubrication performance, its wear stability remains limited. On the other hand, the low wear observed in pHEMA-despite its higher friction-suggests strong structural resilience, making it a promising platform for further tailoring toward cartilage-mimicking applications. The results highlight the importance of balancing interfacial lubrication and mechanical durability when designing hydrogel-based cartilage replacements.

Název v anglickém jazyce

Toward Cartilage-Mimicking Biomaterials: Biotribological, Biochemical and Structural Evaluation of pHEMA and PVA-Based Hydrogels

Popis výsledku anglicky

This study compares the biotribological and structural behavior of PVA and pHEMA hydrogels under conditions simulating the cartilage environment to understand the lubrication mechanisms. PVA samples exhibited very low apparent friction coefficients and high-water uptake due to their hydrophilic, hydroxyl-rich network. In contrast, pHEMA hydrogels showed higher friction but substantially enhanced wear resistance, particularly under extended sliding against rough counterfaces. While PVA offers excellent lubrication performance, its wear stability remains limited. On the other hand, the low wear observed in pHEMA-despite its higher friction-suggests strong structural resilience, making it a promising platform for further tailoring toward cartilage-mimicking applications. The results highlight the importance of balancing interfacial lubrication and mechanical durability when designing hydrogel-based cartilage replacements.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20300 - Mechanical engineering

Projekt

<a href="/cs/project/EH22_008%2F0004634" target="_blank" >EH22_008/0004634: Strojní inženýrství biologických a bioinspirovaných systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Omega

ISSN

2470-1343

e-ISSN

2470-1343

Svazek periodika

10

Číslo periodika v rámci svazku

51

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

63441-63454

Kód UT WoS článku

001632722700001

EID výsledku v databázi Scopus

2-s2.0-105026109454