Biomimetic pHEMA Hydrogels as an Alternative Cartilage-like Model Material for Biotribological Evaluations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0199016" target="_blank" >RIV/00216305:26620/26:0199016 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsomega.5c05569" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.5c05569</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsomega.5c05569" target="_blank" >10.1021/acsomega.5c05569</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biomimetic pHEMA Hydrogels as an Alternative Cartilage-like Model Material for Biotribological Evaluations

Popis výsledku v původním jazyce

Poly(vinyl alcohol) (PVA) has been widely explored as a model material for articular cartilage (AC) in biotribological evaluations. However, PVA hydrogels prepared by freeze-thawing or cast-drying methods have limitations in precisely controlling their elasticity parameters and may require reinforcement to enhance their mechanical performance and change their transparency, required in some tribological measurement setups by using fluorescence methods. To overcome these issues, poly(hydroxyethyl methacrylate) (pHEMA) hydrogels have been introduced as alternatives. In our study, pHEMA hydrogels synthesized using free-radical polymerization with blue light under two different atmospheres (nitrogen N2 and air) were compared with natural samples of articular bovine cartilage. The optical, mechanical, swelling, and tribological properties demonstrate the superior properties of pHEMA, which may result in the replacement of the currently used PVA-based model in future studies. Synthesis under a nitrogen atmosphere (pHEMA N 2) resulted in the formation of smooth-surfaced hydrogels, whereas synthesis under a laboratory atmosphere (pHEMA air) resulted in the formation of wrinkled-surfaced hydrogels. The swelling of both the hydrogels and AC followed first-order kinetics. Pin-on-plate biotribology measurements showed that the coefficient of friction of the wrinkled-surface hydrogels resembled that of AC. Our results showed that pHEMA-based hydrogels are suitable biotribological AC models for a better understanding of the biological functions of bovine AC. This knowledge brings new insights into cartilage complex mechanisms and might be applied in both biomedical and engineering applications.

Název v anglickém jazyce

Biomimetic pHEMA Hydrogels as an Alternative Cartilage-like Model Material for Biotribological Evaluations

Popis výsledku anglicky

Poly(vinyl alcohol) (PVA) has been widely explored as a model material for articular cartilage (AC) in biotribological evaluations. However, PVA hydrogels prepared by freeze-thawing or cast-drying methods have limitations in precisely controlling their elasticity parameters and may require reinforcement to enhance their mechanical performance and change their transparency, required in some tribological measurement setups by using fluorescence methods. To overcome these issues, poly(hydroxyethyl methacrylate) (pHEMA) hydrogels have been introduced as alternatives. In our study, pHEMA hydrogels synthesized using free-radical polymerization with blue light under two different atmospheres (nitrogen N2 and air) were compared with natural samples of articular bovine cartilage. The optical, mechanical, swelling, and tribological properties demonstrate the superior properties of pHEMA, which may result in the replacement of the currently used PVA-based model in future studies. Synthesis under a nitrogen atmosphere (pHEMA N 2) resulted in the formation of smooth-surfaced hydrogels, whereas synthesis under a laboratory atmosphere (pHEMA air) resulted in the formation of wrinkled-surfaced hydrogels. The swelling of both the hydrogels and AC followed first-order kinetics. Pin-on-plate biotribology measurements showed that the coefficient of friction of the wrinkled-surface hydrogels resembled that of AC. Our results showed that pHEMA-based hydrogels are suitable biotribological AC models for a better understanding of the biological functions of bovine AC. This knowledge brings new insights into cartilage complex mechanisms and might be applied in both biomedical and engineering applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/EH22_008%2F0004634" target="_blank" >EH22_008/0004634: Strojní inženýrství biologických a bioinspirovaných systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Omega

ISSN

2470-1343

e-ISSN

2470-1343

Svazek periodika

10

Číslo periodika v rámci svazku

38

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

44147-44161

Kód UT WoS článku

001571666200001

EID výsledku v databázi Scopus

2-s2.0-105017408200