Analysis of Dynamic Changes in ECG Signals During Optical Mapping By Dynamic Time Warping

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of Dynamic Changes in ECG Signals During Optical Mapping By Dynamic Time Warping

Popis výsledku v původním jazyce

Voltage-sensitive dyes (VSDs) are used in touch-less recording of electrical activity from animal hearts. VSD's undergo changes in their fluorescence spectra, in response to changes in the surrounding electric field. This optical response is sufficientlyfast to detect transient potential changes in excitable cardiac cells. However, our previous Langendorf perfused heart studies have suggested changes in ECG signals in time and time-frequency domain caused by application of VSD during optical mapping. DDetailed analysis of changes is needed to reveal impact to particular fractions of a heart cycle. Rabbit hearts are employed in our laboratory to record monophasic action potentials using VSDs in isolated hearts perfused according to Langendorf. The spontaneously beating heart is mounted on Langendorf set and perfused with constant perfusion pressure with Krebs-Henseleit solution (37°C, 1,25mM Ca2+). After control period (20 min), the heart is loaded with di-4-ANEPPS (2uM) diluted in per

Název v anglickém jazyce

Analysis of Dynamic Changes in ECG Signals During Optical Mapping By Dynamic Time Warping

Popis výsledku anglicky

Voltage-sensitive dyes (VSDs) are used in touch-less recording of electrical activity from animal hearts. VSD's undergo changes in their fluorescence spectra, in response to changes in the surrounding electric field. This optical response is sufficientlyfast to detect transient potential changes in excitable cardiac cells. However, our previous Langendorf perfused heart studies have suggested changes in ECG signals in time and time-frequency domain caused by application of VSD during optical mapping. DDetailed analysis of changes is needed to reveal impact to particular fractions of a heart cycle. Rabbit hearts are employed in our laboratory to record monophasic action potentials using VSDs in isolated hearts perfused according to Langendorf. The spontaneously beating heart is mounted on Langendorf set and perfused with constant perfusion pressure with Krebs-Henseleit solution (37°C, 1,25mM Ca2+). After control period (20 min), the heart is loaded with di-4-ANEPPS (2uM) diluted in per

Druh

D - Stať ve sborníku

CEP obor

JD - Využití počítačů, robotika a její aplikace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computers in Cardiology

ISBN

0-7803-8894-1

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

1-4

Název nakladatele

IEEE

Místo vydání

Francie

Místo konání akce

Lyon

Datum konání akce

25. 9. 2005

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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