Model of Preconditioning in Guinea Pig and Rabbit Isolated Hearts Loaded with Voltage-Sensitive Dye Di-4-ANEPPS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F09%3APU82547" target="_blank" >RIV/00216305:26220/09:PU82547 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Model of Preconditioning in Guinea Pig and Rabbit Isolated Hearts Loaded with Voltage-Sensitive Dye Di-4-ANEPPS

Popis výsledku v původním jazyce

Cardiovascular system diseases are frequent cause of morbidity and mortality in Western countries. In our laboratory, early stages of ischemia - prominent diagnosis in this group - are examined by recording electrograms and action potentials by optical probe in isolated mammalian hearts loaded with voltage-sensitive dye (VSD) di-4-ANEPPS. In this study, guinea pig and rabbit isolated hearts were exposed to special protocol of s.-c. preconditioning - attenuation of the symptoms during repeated exposure to ischemic insult. In guinea pig myocardium, additive effect of VSD and ischemia triggered more serious and more frequent arrhythmias then the same situation in rabbit hearts. Moreover, expected attenuation of these effects was not observed, on the contrary to rabbit myocardium, where typical preconditioning was present. Rabbit myocardium appears to be more suitable for studies in such experimental design.

Název v anglickém jazyce

Model of Preconditioning in Guinea Pig and Rabbit Isolated Hearts Loaded with Voltage-Sensitive Dye Di-4-ANEPPS

Popis výsledku anglicky

Cardiovascular system diseases are frequent cause of morbidity and mortality in Western countries. In our laboratory, early stages of ischemia - prominent diagnosis in this group - are examined by recording electrograms and action potentials by optical probe in isolated mammalian hearts loaded with voltage-sensitive dye (VSD) di-4-ANEPPS. In this study, guinea pig and rabbit isolated hearts were exposed to special protocol of s.-c. preconditioning - attenuation of the symptoms during repeated exposure to ischemic insult. In guinea pig myocardium, additive effect of VSD and ischemia triggered more serious and more frequent arrhythmias then the same situation in rabbit hearts. Moreover, expected attenuation of these effects was not observed, on the contrary to rabbit myocardium, where typical preconditioning was present. Rabbit myocardium appears to be more suitable for studies in such experimental design.

Druh

D - Stať ve sborníku

CEP obor

JD - Využití počítačů, robotika a její aplikace

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computers in Cardiology

ISBN

0-7803-8894-1

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

—

Název nakladatele

IEEE

Místo vydání

Park City, Utah

Místo konání akce

Park City, Utah

Datum konání akce

13. 9. 2009

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—