EXPERIMENTAL USE OF NOVEL PULSE GENERATOR FOR IRREVERSIBLE ELECTROPORATION

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F17%3APU123515" target="_blank" >RIV/00216305:26220/17:PU123515 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EXPERIMENTAL USE OF NOVEL PULSE GENERATOR FOR IRREVERSIBLE ELECTROPORATION

Popis výsledku v původním jazyce

Irreversible electroporation (IRE) is a relatively new technique for minimal invasive nonthermal ablation treatment of solid tumors. This article describes basics of IRE and available devices for this technique. The parameters of commercial NanoKnife IRE generator are verified and the unique experimental IRE generator developed at the Brno University of Technology is presented in this paper. Further, there is a comparison of thermal effects on a target tissue of commonly used radiofrequency ablation (RFA) and the novel IRE generator using an infrared camera. All experiments were performed ex vivo on a porcine liver. The difference in maximum temperature between the output powers used was 17.8 °C with RFA and 3 °C with IRE. This is a significant difference and shows the IRE’s capability of liver tissue ablation without thermal damage. The new IRE generator is also capable of replacing NanoKnife because of its features and versatility.

Název v anglickém jazyce

EXPERIMENTAL USE OF NOVEL PULSE GENERATOR FOR IRREVERSIBLE ELECTROPORATION

Popis výsledku anglicky

Irreversible electroporation (IRE) is a relatively new technique for minimal invasive nonthermal ablation treatment of solid tumors. This article describes basics of IRE and available devices for this technique. The parameters of commercial NanoKnife IRE generator are verified and the unique experimental IRE generator developed at the Brno University of Technology is presented in this paper. Further, there is a comparison of thermal effects on a target tissue of commonly used radiofrequency ablation (RFA) and the novel IRE generator using an infrared camera. All experiments were performed ex vivo on a porcine liver. The difference in maximum temperature between the output powers used was 17.8 °C with RFA and 3 °C with IRE. This is a significant difference and shows the IRE’s capability of liver tissue ablation without thermal damage. The new IRE generator is also capable of replacing NanoKnife because of its features and versatility.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20201 - Electrical and electronic engineering

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 23nd Conference STUDENT EEICT 2017

ISBN

978-80-214-5496-5

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

568-572

Název nakladatele

Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních

Místo vydání

první

Místo konání akce

Brno

Datum konání akce

27. 4. 2017

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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