The identification of replication origin in bacterial genomes by cumulated phase signal

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F17%3APU124947" target="_blank" >RIV/00216305:26220/17:PU124947 - isvavai.cz</a>

Výsledek na webu

<a href="http://ieeexplore.ieee.org/abstract/document/8058561/" target="_blank" >http://ieeexplore.ieee.org/abstract/document/8058561/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/CIBCB.2017.8058561" target="_blank" >10.1109/CIBCB.2017.8058561</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The identification of replication origin in bacterial genomes by cumulated phase signal

Popis výsledku v původním jazyce

The origin of replication (oriC) plays an important role in the cell cycle as the place where DNA replication is initiated. In bacterial cells, a single replication origin can be found and its correct identification is necessary in the annotation process of newly sequenced genomes. Although the rearrangement of a whole genome sequence according to oriC should be a standard procedure, public databases still contain lots of genomes starting at a random place. This situation complicates the comparative analysis of whole bacterial genomes as only two genomes rearranged according to oriC can be reliably aligned. In this paper, we present a novel technique for oriC prediction based exclusively on utilization of cumulated phase signal which distinguishes our approach from current techniques combining application of genomic signal processing techniques with a standard character based comparison. Proposed technique is therefore fast and suitably complements the current pipeline for comparison of whole bacterial genomes by aligned downsampled signals.

Název v anglickém jazyce

The identification of replication origin in bacterial genomes by cumulated phase signal

Popis výsledku anglicky

The origin of replication (oriC) plays an important role in the cell cycle as the place where DNA replication is initiated. In bacterial cells, a single replication origin can be found and its correct identification is necessary in the annotation process of newly sequenced genomes. Although the rearrangement of a whole genome sequence according to oriC should be a standard procedure, public databases still contain lots of genomes starting at a random place. This situation complicates the comparative analysis of whole bacterial genomes as only two genomes rearranged according to oriC can be reliably aligned. In this paper, we present a novel technique for oriC prediction based exclusively on utilization of cumulated phase signal which distinguishes our approach from current techniques combining application of genomic signal processing techniques with a standard character based comparison. Proposed technique is therefore fast and suitably complements the current pipeline for comparison of whole bacterial genomes by aligned downsampled signals.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

<a href="/cs/project/GA17-01821S" target="_blank" >GA17-01821S: Výkonnostní techniky pro sestavování a anotaci bakteriálního genomu využívající číslicové zpracování genomických signálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

2017 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)

ISBN

978-1-4673-8988-4

ISSN

—

e-ISSN

—

Počet stran výsledku

5

Strana od-do

267-271

Název nakladatele

IEEE

Místo vydání

neuveden

Místo konání akce

Manchester

Datum konání akce

23. 8. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000463852500041