Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F18%3APU127859" target="_blank" >RIV/00216305:26220/18:PU127859 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ifacol.2018.07.127" target="_blank" >http://dx.doi.org/10.1016/j.ifacol.2018.07.127</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ifacol.2018.07.127" target="_blank" >10.1016/j.ifacol.2018.07.127</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State

Popis výsledku v původním jazyce

Respiratory diseases are ubiquitous among European citizens and their prevalence is increasing steadily. Deeper insight into the respiratory process can be gained by modelling of the region of interest in the human body. The presented lung simulator xPULM bridges the gap between in-silico (mathematical), in-vivo (cell culture based) and mechanical models of the respiratory tract. By adopting selected mathematical models of the human respiratory tract two scenarios were simulated. The linear mathematical single compartment model was used for simulation of the human breathing pattern at rest. Higher complexity non-linear mathematical model reflecting diverse nature of the human respiratory tract was used as a basis for simulation of an artificially ventilated patient. The time-flow characteristics of the mathematical models have been implemented into the control software of the mechanical lung simulator - xPULM. The simulator was then configured to replicate these required breathing patterns employing feedback control loop. The airflow was measured over the course of breathing simulation. The results show high conformity of required and measured breathing patterns characteristic with steady frequency rate and minimal airflow variability. Furthermore, xPULM was capable of reproducing rapid changes of airflow occurring during simulation of artificially ventilated patient, showing high versatility and adaptability of the simulator. Future research will focus on reduction of flow fluctuations and implementation of new breathing patterns. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Název v anglickém jazyce

Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State

Popis výsledku anglicky

Respiratory diseases are ubiquitous among European citizens and their prevalence is increasing steadily. Deeper insight into the respiratory process can be gained by modelling of the region of interest in the human body. The presented lung simulator xPULM bridges the gap between in-silico (mathematical), in-vivo (cell culture based) and mechanical models of the respiratory tract. By adopting selected mathematical models of the human respiratory tract two scenarios were simulated. The linear mathematical single compartment model was used for simulation of the human breathing pattern at rest. Higher complexity non-linear mathematical model reflecting diverse nature of the human respiratory tract was used as a basis for simulation of an artificially ventilated patient. The time-flow characteristics of the mathematical models have been implemented into the control software of the mechanical lung simulator - xPULM. The simulator was then configured to replicate these required breathing patterns employing feedback control loop. The airflow was measured over the course of breathing simulation. The results show high conformity of required and measured breathing patterns characteristic with steady frequency rate and minimal airflow variability. Furthermore, xPULM was capable of reproducing rapid changes of airflow occurring during simulation of artificially ventilated patient, showing high versatility and adaptability of the simulator. Future research will focus on reduction of flow fluctuations and implementation of new breathing patterns. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 15th IFAC Conference on Programmable Devices and Embedded Systems PDeS 2018

ISBN

—

ISSN

2405-8963

e-ISSN

—

Počet stran výsledku

6

Strana od-do

42-47

Název nakladatele

Neuveden

Místo vydání

neuveden

Místo konání akce

Ostrava

Datum konání akce

23. 5. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000445644900008