Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F18%3APU129627" target="_blank" >RIV/00216305:26220/18:PU129627 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/18:00501676

Výsledek na webu

<a href="https://ieeexplore.ieee.org/document/8744067" target="_blank" >https://ieeexplore.ieee.org/document/8744067</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.22489/CinC.2018.055" target="_blank" >10.22489/CinC.2018.055</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart

Popis výsledku v původním jazyce

Syndromes of ventricular pre-excitation or atrio-ventricular (AV) re-entry are believed to results from inappropriate formation of AV junction (AVJ) during prenatal development. However, technical limitations have challenge to study foetal heart electrophysiology and are hampering the understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of rethrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during whole prenatal periods. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of AV electrical continuity was still detected in post-septated foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none APs were detected in prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling and spatiotemporally localise electrically active APs in the critical growing eriods.

Název v anglickém jazyce

Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart

Popis výsledku anglicky

Syndromes of ventricular pre-excitation or atrio-ventricular (AV) re-entry are believed to results from inappropriate formation of AV junction (AVJ) during prenatal development. However, technical limitations have challenge to study foetal heart electrophysiology and are hampering the understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of rethrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during whole prenatal periods. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of AV electrical continuity was still detected in post-septated foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none APs were detected in prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling and spatiotemporally localise electrically active APs in the critical growing eriods.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology 2018

ISBN

—

ISSN

2325-887X

e-ISSN

—

Počet stran výsledku

4

Strana od-do

1-4

Název nakladatele

Neuveden

Místo vydání

Maastricht

Místo konání akce

Maastricht

Datum konání akce

23. 9. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000482598700281